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Epigenome Remodeling in Cholangiocarcinoma
Colm J O'Rourke1, Juan Lafuente-Barquero1, Jesper B Andersen1
1Biotech Research and Innovation Centre (BRIC), Department of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark.
Trends in Cancer
|June 19, 2019
Summary
Cholangiocarcinoma (CCA) research can advance by focusing on epigenetics. Understanding epigenome dysregulation offers new avenues for biomarkers and treatments for this challenging cancer.
Area of Science:
- Oncology
- Epigenetics
- Cancer Biology
Background:
- Cholangiocarcinoma (CCA) is a group of biliary tract cancers with poor prognosis and treatment resistance.
- Recurrent mutations in epigenetic regulators suggest epigenetic destabilization is key in CCA development.
- Biliary tumor epigenomes remain understudied, limiting our understanding of CCA.
Purpose of the Study:
- To advocate for an epigenome-oriented approach in cholangiocarcinoma research.
- To explore the links between epigenetics, molecular heterogeneity, cell origins, and tumor microenvironments in CCA.
- To discuss factors contributing to epigenome dysregulation and assess the translational potential of epigenomics in CCA.
Main Methods:
- This is an Opinion article, presenting a perspective on the role of epigenetics in CCA.
- It synthesizes current knowledge on CCA, epigenetic regulators, and potential causes of epigenome dysregulation.
- It assesses the potential of epigenomic approaches for biomarker and therapeutic development.
Main Results:
- An epigenome-focused strategy can connect diverse aspects of CCA research, including heterogeneity and the tumor microenvironment.
- Epigenome dysregulation in biliary tumors may stem from genetic, epigenetic, metabolic, microenvironmental, and physiological factors.
- Epigenomic insights hold promise for identifying novel biomarkers and therapeutic targets for CCA.
Conclusions:
- An epigenome-oriented approach is crucial for advancing cholangiocarcinoma research and understanding its complexities.
- Investigating the causes and consequences of epigenome dysregulation can reveal new therapeutic strategies.
- Epigenomics offers significant translational potential for developing effective treatments and biomarkers for CCA patients.
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