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Gastroenteritis, Hepatitis, Encephalopathy, and Human Herpesvirus 6 Detection in an Immunocompetent Child: Benefits
Christina A Olson1, Samuel R Dominguez1, Steve Miller2
1Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO; Children's Hospital Colorado, Aurora, CO.
Insights
A toddler with gastroenteritis, encephalopathy, and hepatitis was diagnosed with primary human herpesvirus 6B (HHV-6B) infection. Advanced molecular testing confirmed the virus as the cause of severe illness in this immunocompetent child.
Area of Science:
- Pediatrics
- Virology
- Infectious Diseases
Background:
- Gastroenteritis, encephalopathy, and hepatitis can present with overlapping symptoms.
- Human herpesvirus 6 (HHV-6) is a common viral pathogen, typically causing mild illness, but can lead to severe disease in certain contexts.
- Primary HHV-6 infection is often subclinical or presents with nonspecific symptoms in immunocompetent individuals.
Abstract:
An immunocompetent toddler came to medication attention with gastroenteritis, complicated by encephalopathy and hepatitis. Multiplexed testing using a polymerase chain reaction meningitis panel was positive for human herpesvirus 6 (HHV-6). Clinical correlation, quantitative HHV-6 polymerase chain reaction, and metagenomic next-generation sequencing supported a likely diagnosis of primary HHV-6B infection.
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