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Related Concept Videos

Hypoxia01:23

Hypoxia

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Hypoxia is a medical condition characterized by an inadequate oxygen supply to body tissues. It typically manifests as a bluish discoloration of the skin and mucosae, especially in fair-skinned individuals, when hemoglobin (Hb) saturation drops below 75%.
Types of Hypoxia
There are four primary types of hypoxia, each resulting from a different cause:
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Pulmonary Tuberculosis I01:29

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Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
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Pulmonary Tuberculosis II01:28

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Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
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Pulmonary Tuberculosis V01:28

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Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
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Gene Therapy00:59

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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
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Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
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Related Experiment Video

Updated: Jan 23, 2026

An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
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Revisiting hypoxia therapies for tuberculosis.

Stefan H Oehlers1,2

  • 1Tuberculosis Research Program at the Centenary Institute, The University of Sydney, Camperdown, NSW 2050, Australia stefan.oehlers@sydney.edu.au.

Clinical Science (London, England : 1979)
|June 19, 2019
PubMed
Summary

Novel therapies are needed to combat drug-resistant tuberculosis. This study proposes using anti-angiogenic therapy to induce hypoxia, a host-directed approach to treat tuberculosis by targeting bacterial tumors.

Keywords:
Mycobacterium tuberculosisangiogenesishypoxiavascular endothelial growth factor

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Area of Science:

  • Immunology
  • Infectious Diseases
  • Oncology

Background:

  • The rise of antibiotic-resistant tuberculosis (TB) necessitates innovative treatment strategies.
  • Host-directed therapies (HDTs) offer a promising avenue by targeting host processes rather than bacteria directly.
  • The TB granuloma shares characteristics with tumors, suggesting potential therapeutic parallels.

Purpose of the Study:

  • To investigate the efficacy of inducing hypoxia via anti-angiogenic therapy as a host-directed treatment for tuberculosis.
  • To propose anti-angiogenic therapy as a modernized approach to historical sanatoria treatments for TB.
  • To explore the potential of treating the TB granuloma as a 'bacterial tumor'.

Main Methods:

  • Hypothesizing the induction of hypoxia through anti-angiogenic therapy.
  • Conceptualizing the TB granuloma as a 'bacterial tumor' amenable to anti-angiogenic treatment.
  • Defining experimental tools to validate the proposed therapeutic strategy.

Main Results:

  • Anti-angiogenic therapy is hypothesized to reduce bacterial burden by inducing dormancy.
  • This approach is expected to activate host hypoxia-induced factor (HIF)-mediated immunity.
  • The strategy aims to spare host immunopathology while targeting the infection.

Conclusions:

  • Anti-angiogenic therapy represents a novel host-directed strategy against drug-resistant tuberculosis.
  • The proposed mechanism involves inducing bacterial dormancy and enhancing host immunity via hypoxia.
  • Further experimental validation is required to establish this approach as an effective TB treatment.