The Role of Memory CD8⁺ T Cells in Vitiligo

Vitiligo is an autoimmune skin disease mediated by autoreactive CD8⁺ T cells that destroy the pigment-producing cells of the epidermis, melanocytes, leading to areas of depigmentation. Patients with vitiligo require lifelong treatment to regain and maintain their pigment. Clinical observations uncovered the importance of autoimmune memory in vitiligo because cessation of treatment frequently led to relapse of disease at the site of previous lesions. A subset of memory T cells known as CD8⁺ resident memory T cells (T_RM) are long-lived, nonmigratory memory cells that persist in most nonlymphoid tissues, including the skin. Recent reports describe the presence of CD8⁺ T_RM in lesional vitiligo patient skin and suggest their role as active players in disease maintenance. In this review, we will discuss the role of skin CD8⁺ T_RM in maintaining disease in vitiligo and the opportunity to target this population to induce a long-lasting reversal of disease.