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Control of growth factor signalling by MACPF proteins
Daniel Bakopoulos1, James C Whisstock2,3, Travis K Johnson4,5
1School of Biological Sciences, Monash University, Clayton, VIC 3800, Australia.
Biochemical Society Transactions
|June 19, 2019
Summary
The membrane attack complex/perforin-like (MACPF) superfamily proteins, known for cell lysis, also regulate developmental signaling. This review explores how MACPF domains were repurposed for development, not just cell killing.
Area of Science:
- Biochemistry
- Cell Biology
- Developmental Biology
Background:
- Members of the membrane attack complex/perforin-like (MACPF) protein superfamily form pores on cell surfaces.
- These proteins are well-characterized for their roles in vertebrate immunity, inducing cell lysis and apoptosis.
- Emerging evidence suggests MACPF proteins also regulate cellular signaling and developmental processes.
Purpose of the Study:
- To examine the link between pore-forming MACPF proteins and growth factor/cytokine signaling.
- To reconcile the evolution of the MACPF domain for developmental roles beyond cell killing.
Main Methods:
- Literature review and synthesis of existing research on MACPF proteins.
- Analysis of examples like Torso-like (Tsl) in Drosophila development.
Main Results:
- MACPF proteins are implicated in controlling growth factor and cytokine signaling pathways.
- Evidence suggests a functional divergence from lytic pore formation to developmental regulation.
Conclusions:
- The MACPF domain has been evolutionarily repurposed for diverse cellular functions, including development.
- Understanding the non-lytic functions of MACPF proteins is crucial for comprehending their broader biological roles.
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