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A small-molecule inhibitor of C5 complement protein.

Keith Jendza1, Mitsunori Kato1, Michael Salcius2

  • 1Global Discovery Chemistry, Novartis Institutes of Biomedical Research, Cambridge, MA, USA.

Nature Chemical Biology
|June 19, 2019
PubMed
Summary

Researchers developed the first small-molecule inhibitor targeting complement component 5 (C5). This discovery offers a new therapeutic strategy for diseases driven by uncontrolled complement pathway activation.

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