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Serum Irisin, Adropin, and Preptin in Obese Patients 6 Months After Bariatric Surgery
M Glück1, J Glück2, M Wiewióra3
1Department of General and Bariatric Surgery and Emergency Medicine, Medical University of Silesia, Zabrze, Poland. marekgluck46@gmail.com.
Background/Objectives:
The reduction of body mass after bariatric surgery affects energy metabolism and may involve changes in irisin, preptin, and adropin production.
Subjects And Methods:
Fifty-five morbidly obese patients with a mean body mass index (BMI) of 45.7 ± 5.8 kg/m2 were treated with either laparoscopic sleeve gastrectomy(n = 30) or laparoscopic adjustable gastric banding (n = 25). Forty-six (83.6%) were followed-up 6 months after surgery. The control group included 15 healthy non-obese participants. Anthropometric measurements, lipid profiles, HbA1c, and serum irisin, preptin, and adropin were assessed at baseline and on follow-up.
Results:
The serum concentrations of all three peptides were higher at 6 months than at baseline but only irisin (p = 0.02) and adropin (p = 0.000001) were significantly higher. The increase in preptin was borderline significant (p = 0.051). Changes of serum concentrations of all three peptides were bidirectional.
Conclusion:
Body mass reduction resulting from bariatric procedures may change the production of energy regulating peptides, but not always in a favorable manner.
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