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Updated: Jan 23, 2026

Duodenal-Jejunal Bypass Surgery in Diet-Induced Obese Diabetic Mice
Published on: October 18, 2024
Duodenal-Jejunal Bypass Maintains Gut Permeability by Suppressing Gut Inflammation
Hideya Kashihara1, Mitsuo Shimada2, Kozo Yoshikawa2
1Department of Surgery, Tokushima University, 3-18-15 Kuramoto-cho, Tokushima, Tokushima, 770-8503, Japan. kashihara.hideya@tokushima-u.ac.jp.
Background:
The aim of this study was to investigate gut inflammation and permeability in rats after duodenal-jejunal bypass (DJB) and in rats injected with a glucagon-like peptide-1 (GLP-1) receptor analog.
Methods:
Twelve male 16-week-old obese diabetic rats were divided into three groups: the DJB group, the sham group, and the group injected daily with a GLP-1 receptor agonist (liraglutide). Gut inflammation and the expression of tight junction protein (claudin-1) were analyzed in the three groups at 8 weeks after surgery.
Results:
The DJB group showed significantly lower levels of gut inflammatory cytokines than the liraglutide group. Claudin-1 showed stronger intensity on immunofluorescent staining in the DJB group than that in the liraglutide group.
Conclusions:
In summary, DJB surgery might maintain gut permeability via suppression of gut inflammation.
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