Related Experiment Video
Updated: Jan 23, 2026
08:51
Statistical Modelling of Cortical Connectivity Using Non-invasive Electroencephalograms
Published on: November 1, 2019
6.0K
Frequency-specific alterations in cortical rhythms and functional connectivity in trigeminal neuralgia
Yanyang Zhang1, Zhiqi Mao1, Longsheng Pan1
1Department of Neurosurgery, Chinese PLA General Hospital, Beijing, 100853, China.
Brain Imaging and Behavior
|June 19, 2019
Summary
Trigeminal neuralgia (TN) disrupts brain activity, reducing low-frequency fluctuations in key areas like the PCC and DLPFC. These changes in brain connectivity correlate with pain intensity, offering insights into chronic pain mechanisms.
Area of Science:
- Neuroscience
- Medical Imaging
- Neurology
Background:
- Chronic pain, such as trigeminal neuralgia (TN), is linked to maladaptive changes in brain function and behavior.
- Altered cerebral information flow is a hallmark of chronic pain conditions.
Purpose of the Study:
- To investigate the impact of classic trigeminal neuralgia (TN) on intrinsic brain activity oscillations using power spectral analysis.
- To identify differences in brain function and functional connectivity between TN patients and healthy controls.
Main Methods:
- Utilized resting-state functional MRI (R-fMRI) to measure amplitude of low-frequency fluctuations (ALFF) and fractional ALFF (fALFF) in 29 TN patients and 34 healthy controls (HCs).
- Analyzed two specific low-frequency bands (slow-5: 0.01-0.027 Hz; slow-4: 0.027-0.073 Hz).
- Performed whole-brain resting-state functional connectivity (rsFC) analyses.
Main Results:
- TN patients exhibited reduced ALFF/fALFF in the posterior cingulate cortex (PCC), left insula, left dorsolateral prefrontal cortex (DLPFC), left putamen, and bilateral temporal lobe in the slow-5 band.
- Weaker functional connectivity was observed in PCC-medial prefrontal cortex (mPFC) and DLPFC-hippocampus circuits in TN patients, indicating altered default mode network (DMN) interactions.
- Functional connectivity within DMN regions (mPFC and PCC) in the slow-5 band correlated with reported pain intensity.
Conclusions:
- Trigeminal neuralgia significantly disturbs cortical rhythms and functional brain interactions, particularly within the default mode network.
- These findings provide novel insights into the neural underpinnings of chronic pain and may inform future treatment strategies for TN and other chronic pain conditions.
Related Concept Videos
01:17Functions of Connective Tissues
14.9K
Connective tissues perform a broad range of functions in the body. Their primary function is to connect and link different tissues in the body and act as packaging material between tissues. The areolar tissue, a connective tissue prototype, commonly cements various tissue types in diverse body organs. In contrast, adipose tissue cushions internal organs while insulating the body from heat loss.
Hard connective tissues, such as bones and cartilage, provide structure and support to the body.
Hard connective tissues, such as bones and cartilage, provide structure and support to the body.
14.9K
01:30Pulse rhythm
1.3K
Pulse rhythm refers to the pattern of pulsations within specific intervals, offering valuable insights into the regularity or irregularity of the heart's beats as observed through the pattern of pulsation within specific intervals. A regular pulse exhibits a consistent heart rate with uniform waveforms and pulsation force, variations of which can be classified as normal, weak, or bounding.
Conversely, an irregular pulse pattern is termed dysrhythmia, stemming from disruptions in cardiac...
Conversely, an irregular pulse pattern is termed dysrhythmia, stemming from disruptions in cardiac...
1.3K
01:30Alterations in Respiration II
1.7K
There are numerous types of normal and abnormal respiration. Based on ventilatory movements, breathing patterns are classified as regular, deep, or shallow. Examples include Biot's breathing, Cheyne-Stokes respiration, Kussmaul's breathing, hyperventilation, and hypoventilation. Each pattern is clinically significant and aids in evaluating patients.
In Biot's breathing, the respiratory rate and depth are irregular, alternating between periods of deep gasping and apnea. Common causes...
In Biot's breathing, the respiratory rate and depth are irregular, alternating between periods of deep gasping and apnea. Common causes...
1.7K
01:06Altered States of Awareness
1.0K
Altered states of consciousness represent significant deviations from one's normal mental state. These deviations can range from subtle changes in awareness to profound transformations in perception, thought processes, and sensory experiences. Altered states of consciousness can be triggered by various factors, including drug use, meditation, hypnosis, illness, or even intense fatigue.
The ingestion of substances like stimulants or hallucinogens leads to chemical alterations in the brain...
The ingestion of substances like stimulants or hallucinogens leads to chemical alterations in the brain...
1.0K
01:29Disturbances in Heart Rhythm
2.6K
Arrhythmia or dysrhythmia refers to an abnormal heart rhythm caused by a defect in the heart's conduction system. It can cause the heart to beat irregularly, too quickly, or too slowly, leading to symptoms like chest pain, shortness of breath, and fainting. Factors such as stress, caffeine, alcohol, nicotine, cocaine, certain drugs, congenital defects, diseases, and electrolyte abnormalities can trigger arrhythmias.
Arrhythmias are categorized by their speed, rhythm, and origin. A slow heart...
Arrhythmias are categorized by their speed, rhythm, and origin. A slow heart...
2.6K
01:24ECG Interpretation of Rhythms
13.3K
An electrocardiogram (ECG)graphically represents the heart's electrical activity on ECG paper or a monitor.
Components of the Electrocardiogram
The primary components of a normal ECG waveform in Normal sinus rhythm(NSR) include the P wave, PR interval, QRS complex, ST segment, T wave, and occasionally a U wave.
ECG waveforms are divided by vertical and horizontal lines at standard intervals.
The horizontal axis measures time and rate, and the vertical axis measures amplitude or voltage....
Components of the Electrocardiogram
The primary components of a normal ECG waveform in Normal sinus rhythm(NSR) include the P wave, PR interval, QRS complex, ST segment, T wave, and occasionally a U wave.
ECG waveforms are divided by vertical and horizontal lines at standard intervals.
The horizontal axis measures time and rate, and the vertical axis measures amplitude or voltage....
13.3K