Related Experiment Video

Updated: Jan 23, 2026

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles
08:03

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles

Published on: December 1, 2016

9.5K

Targeted Therapies in Non-small-Cell Lung Cancer

Addie Hill1, Rohan Gupta1, Dan Zhao1

  • 1Department of Medical Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.

Cancer Treatment and Research
|June 19, 2019
PubMed

Insights

Precision medicine has transformed non-small cell lung cancer (NSCLC) treatment over 20 years. Identifying specific mutations allows targeted therapies, significantly improving patient survival and outcomes.

Area of Science:

  • Oncology
  • Genomics
  • Translational Medicine

Background:

  • The treatment of non-small cell lung cancer (NSCLC) has evolved significantly.
  • Cytotoxic chemotherapy was the standard, but precision medicine is now central.
  • Targeted therapies offer improved outcomes for patients with specific mutations.

Purpose of the Study:

  • To review the evolution of precision medicine in NSCLC.
  • To discuss landmark trials and current treatment strategies.
  • To explore future therapeutic targets in lung cancer.

Main Methods:

  • Review of historical clinical trials in NSCLC.
  • Analysis of current targeted therapy approaches.
  • Identification of emerging therapeutic targets.

Main Results:

  • Precision medicine has led to improved progression-free and overall survival in NSCLC.
  • Targeted agents demonstrate significant clinical benefit compared to non-targeted approaches.
  • The field is rapidly advancing with new targets under investigation.

Conclusions:

  • Precision medicine represents a paradigm shift in NSCLC treatment.
  • Identifying and targeting specific driver mutations is crucial for patient benefit.
  • Continued research into novel targets promises further advancements in lung cancer therapy.
Keywords:
ImmunotherapyKinase inhibitorsNon-small-cell lung cancer (NSCLC)Tumor mutation burden (TMB)

More Related Videos

Detection of Targetable Alterations in Non-small Cell Lung Cancer using Next-generation Sequencing05:17

Detection of Targetable Alterations in Non-small Cell Lung Cancer using Next-generation Sequencing

Published on: October 10, 2025

364
Radiosensitivity of Cancer Stem Cells in Lung Cancer Cell Lines09:45

Radiosensitivity of Cancer Stem Cells in Lung Cancer Cell Lines

Published on: August 21, 2019

7.5K

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.7K
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
9.9K
Lung Capacity01:47

Lung Capacity

The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures.
56.2K
Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.4K
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.6K
Target Cell Response to Hormones01:22

Target Cell Response to Hormones

Hormones intricately bind to receptors on the surface or within target cells, initiating a cascade of cellular responses.
Notably, the cellular response can be regulated by altering the number of receptors expressed in the cell. For example, prolonged exposure to elevated hormone levels results in a gradual decline or down-regulation in the number of receptors for that specific hormone on the cell surface. Conversely, in response to low hormone levels, cells may use up-regulation, producing an...
5.3K