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Quantifying Three-Dimensional Cell Migration Within and Into Granular Hydrogel Biomaterials
Published on: March 7, 2025
Granular cell cutaneous epithelioid angiomatous nodule
Timothy C Sorrells1, Aubrey Winn2, Daryl J Sulit2
1Department of Pathology, Naval Medical Center, San Diego, California.
Abstract:
Cutaneous epithelioid angiomatous nodule is an uncommon vascular lesion usually described as composed of epithelioid endothelial cells with vesicular nuclei and eosinophilic cytoplasm. A granular cell variant has not been previously described. Endothelial cells can present with granular cytoplasm as documented with reports of granular cell angiosarcoma. The granularity is thought to be due to increased intracytoplasmic lysosomes. We present a case of a benign superficial vascular lesion composed of a sheet-like proliferation of epithelioid endothelial cells with distinctly granular cytoplasm confirmed as of endothelial origin with positive staining for CD31 and ERG.
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