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Leptin and adiponectin levels in obstructive sleep apnea phenotypes.
Zuleyha Bingol1, Ekrem Bilal Karaayvaz2, Aysegul Telci3
1Department of Pulmonary Medicine, Faculty of Medicine, Istanbul University, Istanbul, 34093, Turkey.
Biomarkers in Medicine
|June 19, 2019
Summary
Serum leptin and adiponectin levels vary in obstructive sleep apnea (OSA) patients, particularly in those with severe obesity, female gender, and severe OSA. These adipokine differences highlight distinct OSA phenotypes.
Area of Science:
- Endocrinology
- Sleep Medicine
- Cardiology
Background:
- Obstructive sleep apnea (OSA) is linked to metabolic dysfunction.
- Leptin and adiponectin are key adipokines involved in metabolic regulation.
- Understanding adipokine profiles in OSA phenotypes is crucial for targeted interventions.
Purpose of the Study:
- To investigate serum leptin and adiponectin levels across different obstructive sleep apnea (OSA) phenotypes.
- To identify associations between adipokine levels and OSA severity, obesity, and gender.
Main Methods:
- Study included 146 obese patients diagnosed with OSA.
- Methods comprised spirometry, arterial blood gas analysis, polysomnography, and echocardiography.
- Serum adiponectin and leptin levels were measured.
Main Results:
- Females exhibited higher leptin and adiponectin levels compared to males (p < 0.001 for both).
- Patients with severe obesity had elevated leptin levels (p < 0.001).
- Severe OSA was associated with lower leptin and adiponectin levels (p = 0.023 and p = 0.035, respectively).
Conclusions:
- Adipokine levels, specifically leptin and adiponectin, differ significantly across OSA phenotypes.
- Severe obesity, female gender, and severe OSA are associated with distinct adipokine profiles.
- These findings underscore the heterogeneity of OSA and its metabolic underpinnings.
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