Suboptimal cardiovascular risk management in rheumatoid arthritis patients despite an explicit cardiovascular risk

M Heslinga1, Iam Van Den Oever1, D L Jonker2

  • 1Amsterdam Rheumatology and Immunology Center/Reade , Amsterdam , The Netherlands.

Insights

Cardiovascular risk screening in rheumatoid arthritis (RA) patients identified high-risk individuals. Despite clear guidelines, preventive treatment initiation and lifestyle changes remain challenging for these high-risk RA patients.

Area of Science:

  • Cardiology
  • Rheumatology
  • Public Health

Background:

  • Rheumatoid arthritis (RA) is associated with increased cardiovascular (CV) risk.
  • Early identification and management of CV risk factors are crucial for RA patients.

Purpose of the Study:

  • To assess the initiation of preventive treatment and changes in CV risk scores 1 year after implementing a CV risk screening program for high-risk RA patients.
  • To evaluate the effectiveness of targeted advice and referral in improving CV risk management in RA.

Main Methods:

  • CV risk screening was conducted in a rheumatology clinic and general hospital.
  • Patients identified as high CV risk received targeted advice for preventive drug initiation or adjustment.
  • CV risk, lifestyle, and treatment were reassessed after 1 year; patients with prior CV disease were excluded.

Main Results:

  • 58% of RA patients had a high 10-year CV risk (>20%), with 55% indicated for antihypertensives or statins.
  • Only one-third of patients with an indication for preventive drugs started or adjusted treatment.
  • 42% of patients reported lifestyle changes, including increased exercise, diet modification, and weight loss.

Conclusions:

  • Implementing CV risk screening and providing targeted advice in RA patients is essential but challenging.
  • Primary prevention of CV disease in high-risk RA patients requires further improvement despite established guidelines.
  • Active screening programs need to be optimized to ensure adequate uptake of indicated preventive treatments and lifestyle modifications.

Related Concept Videos

Overview of the Cardiovascular System01:14

Overview of the Cardiovascular System

The cardiovascular system is a vital transportation system in the body. It comprises the heart and blood vessels and facilitates the exchange of gases, nutrients, and waste products.
Heart
The heart is the central pump of the cardiovascular system that circulates blood throughout the body. It comprises two atria receiving the blood and two ventricles pumping blood out of the heart. Their rhythmic contractions, called heartbeats, ensure that blood flow remains continuous.
Blood Vessels
Blood...
11.1K
Relative Risk01:12

Relative Risk

Relative risk (RR) is a statistical measure commonly used in epidemiology to compare the likelihood of a particular event occurring between two groups. This metric is important for evaluating the relationship between exposure to a specific risk factor and the probability of a particular outcome. It plays a crucial role in medical research, public health studies, and risk assessment. Relative risk quantifies how much more (or less) likely an event is to occur in an exposed group compared to an...
2.0K
Regulation of the Cardiovascular System01:27

Regulation of the Cardiovascular System

The regulation of the cardiovascular system allows the body to adapt to various demands and maintain homeostasis.
The regulation of the cardiovascular system involves the autonomic nervous system (ANS), baroreceptors, and chemoreceptors, ensuring that heart rate and blood pressure are appropriately modulated in response to varying physiological demands.
The ANS comprises two main divisions: the sympathetic and parasympathetic nervous systems. The sympathetic nervous system enhances...
3.8K
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.3K
Exercise and Cardiovascular Response01:20

Exercise and Cardiovascular Response

Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
3.9K
Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
429