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Updated: Jan 23, 2026

Free Radicals in Chemical Biology: from Chemical Behavior to Biomarker Development
Published on: April 15, 2013
Transition-metal free oxidative C-H etherification of acylanilines with alcohols through a radical pathway
Xiaobo Xu1, Zhengzhou Chu2, Chengcai Xia3
1Shanghai Synmedia Chemical Co., Ltd, Shanghai 201201, China and Pharmacy College, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian 271000, China. xiachc@163.com.
Abstract:
A transition metal free approach for the synthesis of methyl/ethyl aryl ether via oxidative C-H etherification of acylanilines with alcohols has been developed. Various acylanilines are compatible under standard conditions, giving the corresponding products in moderate to good yields. This strategy avoids transition-metal catalyst and excessive alcohol, providing a simple and reliable alternative method for the synthesis of methyl/ethyl aryl ether. Control experiments reveal that a radical mechanism is involved in this transformation.
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