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Related Experiment Video

Updated: Jan 23, 2026

Building a Better Mosquito: Identifying the Genes Enabling Malaria and Dengue Fever Resistance in A. gambiae and A. aegypti Mosquitoes

Building a Better Mosquito: Identifying the Genes Enabling Malaria and Dengue Fever Resistance in A. gambiae and A. aegypti Mosquitoes

Published on: July 4, 2007

Artemether for severe malaria.

Ekpereonne B Esu¹, Emmanuel E Effa, Oko N Opie

¹Department of Public Health, College of Medical Sciences, University of Calabar, Calabar, Cross River State, Nigeria.

The Cochrane Database of Systematic Reviews

|June 19, 2019

Summary

This summary is machine-generated.

Intramuscular artemether shows comparable efficacy to quinine in children but may reduce mortality in adults. However, artemether appears less effective than artesunate in adults with severe malaria.

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Area of Science:

Tropical Medicine
Infectious Diseases
Pharmacology

Background:

The World Health Organization (WHO) recommends parenteral artesunate over quinine for severe malaria.
Artemether, an artemisinin derivative, is used in many countries as an alternative treatment.
This review compares intramuscular artemether with quinine and artesunate for severe malaria.

Purpose of the Study:

To assess the efficacy and safety of intramuscular artemether versus other parenteral antimalarials.
To evaluate artemether's effectiveness in treating severe malaria in adults and children.

Main Methods:

Systematic review of randomized controlled trials (RCTs).
Searched multiple databases including Cochrane, MEDLINE, Embase, and clinical trial registries.
Extracted data on all-cause mortality, coma resolution, neurological sequelae, and parasite/fever clearance times.

Main Results:

In children, artemether showed little difference in mortality compared to quinine but faster parasite clearance.
In adults, artemether likely reduced mortality compared to quinine.
No direct trials compared artemether and artesunate in children; in adults, artemether was associated with higher mortality than artesunate.

Conclusions:

Intramuscular artemether appears more effective than quinine for severe malaria in both children and adults.
Artemether seems inferior to artesunate in adults, supporting WHO's preference for artesunate.
Artemether remains an acceptable alternative when artesunate is unavailable.