Related Experiment Video

Updated: Jan 23, 2026

Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures
06:32

Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures

Published on: January 9, 2019

8.2K

Molecular biomarker-guided anti-angiogenic targeted therapy for malignant glioma

Chengrui Yan1,2, Jiaru Wang2, Yuyan Yang2

  • 1Department of Neurosurgery, Peking University International Hospital, Beijing, China.

Journal of Cellular and Molecular Medicine
|June 19, 2019
PubMed

Insights

Anti-angiogenic therapy shows limited success in malignant glioma treatment. Molecular biomarkers are crucial for stratifying patients and improving treatment efficacy in glioma diagnosis and therapy.

Area of Science:

  • Oncology
  • Molecular Biology
  • Clinical Trials

Background:

  • Malignant glioma has a poor prognosis despite aggressive treatments.
  • Anti-angiogenic therapy is a key cancer treatment but underperforms in malignant glioma.
  • Clinical trials show no overall survival benefits for anti-angiogenic therapy in glioma.

Purpose of the Study:

  • To review current anti-angiogenic drugs in clinical trials for glioma.
  • To discuss the role of molecular biomarkers in guiding glioma diagnosis and treatment.
  • To explore strategies for improving anti-angiogenic therapy outcomes in glioma.

Main Methods:

  • Literature review of anti-angiogenic drugs in clinical trials.
  • Analysis of molecular biomarker applications in glioma.
  • Discussion of challenges and future directions in glioma therapy.

Main Results:

  • Anti-angiogenic therapy has shown limited efficacy in malignant glioma.
  • Molecular biomarkers are essential for patient stratification.
  • Several anti-angiogenic drugs are under investigation in clinical trials.

Conclusions:

  • Personalized medicine approaches using molecular biomarkers are vital for advancing glioma treatment.
  • Further research is needed to optimize anti-angiogenic strategies for glioma patients.
  • Biomarker-guided therapy holds promise for improving outcomes in malignant glioma.
Keywords:
anti-angiogenicbiomarkersgliomamoleculartherapy

More Related Videos

Endoscopic Ultrasound-Guided Biliary Drainage: Endoscopic Ultrasound-Guided Hepaticogastrostomy in Malignant Biliary Obstruction07:44

Endoscopic Ultrasound-Guided Biliary Drainage: Endoscopic Ultrasound-Guided Hepaticogastrostomy in Malignant Biliary Obstruction

Published on: March 25, 2022

6.7K
MR Molecular Imaging of Prostate Cancer with a Small Molecular CLT1 Peptide Targeted Contrast Agent06:54

MR Molecular Imaging of Prostate Cancer with a Small Molecular CLT1 Peptide Targeted Contrast Agent

Published on: September 3, 2013

11.7K

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.7K
Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.4K
Molecular Models02:00

Molecular Models

Physical models representing molecular architectures of chemical compounds play essential roles in understanding chemistry. The use of molecular models makes it easier to visualize the structures and shapes of atoms and molecules.
43.6K
Molecular Orbital Theory II03:51

Molecular Orbital Theory II

Molecular Orbital Energy Diagrams
27.0K
Molecular and Ionic Solids02:54

Molecular and Ionic Solids

Crystalline solids are divided into four types: molecular, ionic, metallic, and covalent network based on the type of constituent units and their interparticle interactions.
Molecular Solids
Molecular crystalline solids, such as ice, sucrose (table sugar), and iodine, are solids that are composed of neutral molecules as their constituent units. These molecules are held together by weak intermolecular forces such as London dispersion forces, dipole-dipole interactions, or hydrogen bonds, which...
20.0K
Molecular Orbital Theory I02:35

Molecular Orbital Theory I

Overview of Molecular Orbital Theory
47.1K