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Incidental findings in pancreas screening programs for high-risk individuals: Results from three European expert

Isaura S Ibrahim¹, Catharina Brückner², Alfredo Carrato³

¹Department of Gastroenterology & Hepatology, Leiden University Medical Center, Leiden, the Netherlands.

United European Gastroenterology Journal

|June 19, 2019

Abstract

Background:

Widespread abdominal imaging has led to a substantial increase in the detection of incidentalomas. Currently, an increasing number of centers offer surveillance of the pancreas to individuals at high risk (IARs) of pancreatic ductal adenocarcinoma (PDAC).

Objective:

The aims of this study were to evaluate the frequency and type of incidental findings in a magnetic resonance imaging (MRI)-based surveillance program for IARs for PDAC, and to discuss the benefit of detecting these lesions.

Methods:

The outcome of MRI screening was reviewed in 568 individuals from three long-term pancreas surveillance programs conducted at three large European expert centers. All MRIs were studied in detail for the presence of incidental lesions.

Results:

The most common lesions were liver cysts, renal cysts and liver hemangioma, which together comprised 75% of all lesions. Only five (0.9%) patients underwent surgery for a benign lesion. Cancer was detected in 11 patients (1.9%); early detection of tumors was beneficial in at least five cases.

Conclusion:

The present study demonstrates that extrapancreatic incidentaloma is a common finding in IARs for PDAC, but rarely requires additional treatment. CDKN2A-p16-Leiden mutation carriers were the only patient group found to harbor a substantial number of cancers, and detection resulted in benefit in several cases.

Keywords:

High-risk individuals PDAC genetic predisposition incidental findings incidentaloma screening surveillance

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