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Open Angle Glaucoma: Treatment01:27

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Association between Platelet Parameters and Glaucoma Severity in Primary Open-Angle Glaucoma.

Yi Ma1,2, Jianping Han1, Shengjie Li1,2

  • 1Department of Clinical Laboratory, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai 200031, China.

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|June 19, 2019
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Platelet distribution width (PDW) and mean platelet volume (MPV) were elevated in primary open-angle glaucoma (POAG) patients. Higher PDW levels correlated with increased POAG severity, suggesting platelet activation may play a role in the disease.

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Area of Science:

  • Ophthalmology
  • Hematology
  • Glaucoma Research

Background:

  • Primary open-angle glaucoma (POAG) is a leading cause of irreversible blindness worldwide.
  • The underlying pathomechanisms of POAG are not fully understood, prompting investigation into various biological factors.
  • Platelets are increasingly recognized for their role beyond hemostasis, including in inflammatory and vascular processes.

Purpose of the Study:

  • To evaluate key platelet parameters in patients diagnosed with primary open-angle glaucoma (POAG).
  • To investigate the potential association between specific platelet parameters and the severity of POAG.
  • To explore the role of platelet activation in the pathomechanisms of POAG.

Main Methods:

  • A cohort study involving 402 POAG patients and 408 healthy controls.
  • Analysis of platelet parameters including platelet count (PLT), platelet distribution width (PDW), plateletcrit (PCT), mean platelet volume (MPV), and platelet large cell ratio (P-LCR) using an automated hematology analyzer.
  • POAG patients were subclassified into mild, moderate, and severe groups based on visual field mean deviation (MD).

Main Results:

  • POAG patients exhibited significantly lower platelet counts (PLT) compared to controls.
  • Elevated levels of platelet distribution width (PDW) and mean platelet volume (MPV) were observed in POAG patients.
  • PDW and MPV values demonstrated a positive correlation with POAG severity, with the highest levels in the severe POAG group; PDW was significantly associated with MD.

Conclusions:

  • Elevated PDW and MPV are significant findings in POAG patients.
  • PDW shows a positive association with POAG disease severity, indicating its potential as a biomarker.
  • These findings suggest that platelet activation may be implicated in the pathomechanisms of primary open-angle glaucoma.