Two Different Meningioma Variants in the Same Tumor: A Rare Histopathological Finding

Area of Science:

• Neuropathology
• Neurosurgery
• Radiology

Background:

• Meningiomas are common primary intracranial tumors arising from meningothelial cells.
• While typically benign, meningiomas can exhibit diverse histological subtypes with varying clinical presentations.
• Secretory and lipomatous features are uncommon histological variants that can influence diagnosis and treatment.

Observation:

• A case of meningioma with concurrent secretory and lipomatous differentiation is described in an advanced middle-aged female.
• The patient presented with a 3-month history of headaches and convulsions, suggestive of intracranial pathology.
• Radiological imaging was crucial in identifying the tumor and guiding further investigation.

Findings:

• Histopathological examination confirmed the presence of both secretory and lipomatous features within the meningioma.
• Review of radiological findings and comparison with existing literature underscore the rarity of this combined histological presentation.
• The tumor's specific features may correlate with the patient's neurological symptoms.

Implications:

• This case expands the understanding of meningioma heterogeneity and its potential for mixed histological features.
• Accurate diagnosis of rare subtypes like this secretory and lipomatous meningioma is essential for appropriate patient management.
• Further research into the molecular mechanisms underlying these combined features could offer new therapeutic insights.