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Updated: Jan 23, 2026

Modeling Spontaneous Metastatic Renal Cell Carcinoma mRCC in Mice Following Nephrectomy
Published on: April 29, 2014
Complete response to perioperative treatment using nivolumab for metastatic renal cell carcinoma: A case report
Daiki Ikarashi1,2, Yasuyuki Nakamura3, Hitoshi Shimodate1
1Department of Urology, Iwate Medical University School of Medicine, 19-1, Uchimaru, Morioka-shi, Iwate, 020-8505, Japan.
Abstract:
We report a case of 59-year-old woman who has multiple lung metastases with renal cell carcinoma (RCC). She received neoadjuvant therapy using nivolumab following sunitinib. Thereafter, we performed cytoreductive nephrectomy and subsequently administered nivolumab. We also found a high expression of PD-L1 in tumor cell and infiltration of lymphocytes with CD8 expression by immunohistochemistry. A complete response was achieved 4 months after surgery. A perioperative treatment using nivolumab might be useful treatment for metastatic RCC.
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