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Updated: Jan 23, 2026
08:14
MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier MSC for Lung Cancer Screening
Published on: October 26, 2017
16.2K
Update on screening for lung cancer.
1Division of Pulmonary & Critical Care Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.
Translational Lung Cancer Research
|June 19, 2019
Summary
Lung cancer screening trials demonstrate significant mortality benefits. This review covers data justifying mass screening and strategies for optimizing lung cancer screening programs for high-risk populations.
Area of Science:
- Oncology
- Public Health
- Radiology
Background:
- Lung cancer is a leading global cause of cancer death, leading to significant suffering and disability.
- Early detection during surgically curable stages dramatically improves cure rates.
- Mass screening of high-risk populations offers substantial potential benefits for lung cancer management.
Purpose of the Study:
- To review trial data supporting mass lung cancer screening.
- To propose strategies for maximizing benefits in public health screening programs.
- To outline methods for minimizing harms associated with lung cancer screening.
Main Methods:
- Non-systematic review of key lung cancer screening trials.
- Analysis of data from the U.S. National Lung Screening Trial (NLST).
- Inclusion of findings from recent European lung cancer screening trials.
Main Results:
- Established evidence supports the mortality benefit of lung cancer screening.
- Screening programs have been implemented widely in the U.S. and internationally.
- European trials corroborate the life-saving potential of lung cancer screening.
Conclusions:
- Trial data provide strong justification for implementing mass lung cancer screening.
- Strategic approaches are necessary to maximize benefits and mitigate harms.
- Public health initiatives should focus on effective lung cancer screening for at-risk individuals.
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