Related Experiment Video
Updated: Jan 23, 2026

Evaluation of Caspase Activation to Assess Innate Immune Cell Death
Published on: January 20, 2023
No apparent effect of naproxen on CSF markers of innate immune activation
Pierre-François Meyer1,2, Anne Labonté2,3, Pedro Rosa-Neto1,2,3,4
1Faculty of Medicine McGill University Montréal Québec Canada.
Abstract:
We studied 78 participants having a parental or multiple-sibling history of Alzheimer's disease (AD) in a two-year randomized placebo-controlled trial of naproxen 220 mg b.i.d. for mitigation of early AD pathogenesis. Naproxen was detected in cerebrospinal fluid at concentrations ~100 times lower than in plasma, but produced negligible change in immune markers. The repeated lack of benefit in AD prevention trials using naproxen and related drugs may reflect limited CNS permeability, lack of expected drug effects, or both. These findings suggest reconsideration of implications from results of AD prevention trials using anti-inflammatory drugs.
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