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PON1 concentration and high-density lipoprotein characteristics as cardiovascular biomarkers
Fátima E Murillo González1,2, Néstor Ponce-RuÍz1,2, Aurora E Rojas-GarcÍa1
1Universidad Autónoma de Nayarit, Laboratorio de Contaminación y Toxicología, Nayarit, Mexico.
Insights
Serum paraoxonase 1 (PON1) levels are lower in cardiovascular disease (CVD) patients. Lower PON1 concentration and altered HDL subclasses may serve as early biomarkers for CVD risk.
Area of Science:
- Biochemistry
- Cardiology
- Biomarkers
Background:
- Serum paraoxonase 1 (PON1) is implicated in cardiovascular diseases (CVD).
- Understanding PON1's role alongside high-density lipoprotein (HDL) subclasses is crucial for CVD risk assessment.
Purpose of the Study:
- To investigate the relationship between PON1 concentration and HDL subclasses in patients with established CVD, cardiovascular risk factors (CRF), and healthy controls.
- To identify potential early biomarkers for CVD development.
Main Methods:
- A case-control study involving 69 participants.
- Evaluation of clinical parameters, lipid profiles, PON1 concentration and activities, and HDL subclasses.
Main Results:
- CVD patients exhibited higher glucose and lower total cholesterol compared to controls.
- PON1 concentration was significantly lower in CVD patients.
- Decreased PON1 levels were associated with the CVD group, but not the CRF group.
- Significant differences in HDL 2a and HDL 3a concentrations were observed between controls and both CRF and CVD groups.
Conclusions:
- PON1 status and HDL characteristics may act as early indicators for predicting CVD development.
- These factors could aid in early risk stratification and intervention strategies for cardiovascular health.
Introduction:
Serum paraoxonase 1 (PON1) is now known to be related to cardiovascular diseases (CVD). The aim of this study was to determine the relationship between PON1 concentration and high-density lipoprotein (HDL) subclasses in patients with proven CVD, cardiovascular risk factors but no CVD (CRF), and in healthy controls (control group).
Material And Methods:
A case-control study was carried out with 69 volunteers from the Mexican Institute of Social Security, Mexico. Clinical parameters, lipid profile, PON1 concentration, PON1 activities (AREase and CMPAase), and HDL subclasses were evaluated.
Results:
Patients with CVD had significantly higher glucose and lower total cholesterol than the control group had (p < 0.01). AREase activity was not different between the control (122.57 ±30.72 U/ml), CRF (115.81 ±32.81 U/ml), and CVD (109.34 ±29.60 U/ml) groups. PON1 concentration was significantly lower in CVD patients than in CRF and control patients (p < 0.001); a positive correlation was observed between AREase activity and PON1 concentration in the CVD group (Rho = 0.58; p < 0.01). Logistic regression analysis showed that the decrease in PON1 level was associated with the CVD group (RRR = 0.20; 95% CI: 0.09-0.45) but not with the CRF group (RRR = 1.29; 95% CI: 0.89-1.90). Significant differences were observed in HDL 2a and HDL 3a concentrations between the control group and CRF and CVD groups (p < 0.05), but not between the CRF and CVD groups.
Conclusions:
Our data suggest that PON1 status and HDL characteristics could be early biomarkers that predict the potential for developing CVD.
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