Related Experiment Video
Updated: Jan 23, 2026

En Face Detection of Nitric Oxide and Superoxide in Endothelial Layer of Intact Arteries
Published on: February 25, 2016
Prevalence of endothelial nitric oxide synthase (ENOS) gene G894T polymorphism and its association with hypertension:
Abel Barbosa Lira Neto1,2, Myrla C O Farias1,2, Nancy B R Vasconcelos1
1Faculty of Nutrition, Federal University of Alagoas, Maceió, AL, Brazil.
Introduction:
Hypertension is one of the most prevalent diseases in the world, accounting for millions of deaths each year. The reduction in the concentration of nitric oxide (NO) produced by the catalysis of endothelial nitric oxide synthase (eNOS) is associated with higher blood pressure (BP) levels. This reduction might be because of genetic polymorphisms. This study investigated the prevalence of the eNOS gene G894T polymorphism in women from northeast Brazil and its association with hypertension.
Material And Methods:
This cross-sectional study included 810 women (aged 19-49 years). Sociodemographic, health, anthropometric, and BP data were collected. Hypertension was defined according to the following criteria: systolic BP ≥ 140 mm Hg, diastolic BP ≥ 90 mm Hg, the regular use of antihypertensive medication, or some combination thereof. Epithelial cells from the cheek mucosa were obtained for DNA extraction. Genotyping was performed via real-time PCR. The measure of association was the prevalence ratio (PR) and its 95% CI as calculated via Poisson regression.
Results:
The frequencies of the GG, GT, and TT genotypes were 57.1%, 35.7%, and 7.2%, respectively. For each of these genotypes, the prevalence of hypertension in women was 17.9%, 23.6%, and 34.4%, respectively. Relative to the GG genotype, the PRs after adjusting for cofounding factors were 1.24 (95% CI: 0.95-1.61, p = 0.11) for GT and 1.76 (95% CI: 1.16-2.67, p < 0.01) for TT.
Conclusions:
The T allele of the G894T polymorphisms is associated with hypertension in women. This may have implications for prevention and treatment.
More Related Videos
08:505/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
Published on: July 3, 2013
08:08Two-photon Imaging of Intracellular Ca2+ Handling and Nitric Oxide Production in Endothelial and Smooth Muscle Cells of an Isolated Rat Aorta
Published on: June 10, 2015
Related Concept Videos
Nitric Oxide Signaling Pathway
Prevalence and Incidence
Prevalence indicates the proportion of individuals in a population who have a specific disease or health...
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...
What is Population Genetics?
Hypertension III: Clinical Manifestations and Diagnostic Studies
ATP Synthase: Mechanism