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Dopamine-GABA interactions in the nucleus accumbens and lateral septum of the rat
B Onténiente1, H Simon, K Taghzouti
1Laboratoire de Physiologie des Interactions Cellulaires, U.A., C.N.R.S. 339, Talence, France.
Abstract:
The relationships between dopaminergic afferents and GABAergic neurones were studied at the electron microscopic level in the rat lateral septum and nucleus accumbens by coupling 6-hydroxydopamine degeneration and gamma-aminobutyric acid (GABA) immunocytochemistry. Degenerating fibres were observed in the two regions making synaptic contact with GABA-immunoreactive and non-labelled cell bodies and dendrites. It is concluded that dopaminergic afferents to the septum and the nucleus accumbens contact, among others, a population of GABAergic cells. A similar route of regulation of the basalo-cortical and septo-hippocampal cholinergic pathways by dopaminergic afferents is proposed.