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Related Concept Videos

Coordination Number and Geometry02:57

Coordination Number and Geometry

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For transition metal complexes, the coordination number determines the geometry around the central metal ion. Table 1 compares coordination numbers to molecular geometry. The most common structures of the complexes in coordination compounds are octahedral, tetrahedral, and square planar.
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Coordination Compounds and Nomenclature02:54

Coordination Compounds and Nomenclature

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In most main group element compounds, the valence electrons of the isolated atoms combine to form chemical bonds that satisfy the octet rule. For instance, the four valence electrons of carbon overlap with electrons from four hydrogen atoms to form CH4. The one valence electron leaves sodium and adds to the seven valence electrons of chlorine to form the ionic formula unit NaCl (Figure 1a). Transition metals do not normally bond in this fashion. They primarily form coordinate covalent bonds, a...
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Lattice Centering and Coordination Number02:33

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The structure of a crystalline solid, whether a metal or not, is best described by considering its simplest repeating unit, which is referred to as its unit cell. The unit cell consists of lattice points that represent the locations of atoms or ions. The entire structure then consists of this unit cell repeating in three dimensions. The three different types of unit cells present in the cubic lattice are illustrated in Figure 1.
Types of Unit Cells
Imagine taking a large number of identical...
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Viral Mutations00:36

Viral Mutations

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A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material...
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Equations of Motion: Rectangular Coordinates and Cylindrical Coordinates01:21

Equations of Motion: Rectangular Coordinates and Cylindrical Coordinates

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Understanding the motion of particles is a fundamental aspect of classical mechanics, and the choice of the coordinate system plays a pivotal role in unraveling the complexities of their dynamics.
When a particle moves relative to an inertial frame, the equations of motion can be expressed using rectangular components. If the motion is confined to the x-y plane, the equations having the x and y coordinates only can be used to simplify the mathematical representation.
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Spherical Coordinates01:23

Spherical Coordinates

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Spherical coordinate systems are preferred over Cartesian, polar, or cylindrical coordinates for systems with spherical symmetry. For example, to describe the surface of a sphere, Cartesian coordinates require all three coordinates. On the other hand, the spherical coordinate system requires only one parameter: the sphere's radius. As a result, the complicated mathematical calculations become simple. Spherical coordinates are used in science and engineering applications like electric and...
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Related Experiment Video

Updated: Jan 23, 2026

Amplifying and Quantifying HIV-1 RNA in HIV Infected Individuals with Viral Loads Below the Limit of Detection by Standard Clinical Assays
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Enhanced care coordination improves HIV viral load suppression rates.

Ross G Hewitt1, Debra Williams, Richard Adule

  • 1MetroPlus Health Plan, 160 Water St, Ste 18W-009, New York, NY 10038.

The American Journal of Managed Care
|June 19, 2019
PubMed
Summary

Targeted outreach and peer support effectively re-engage individuals with HIV (human immunodeficiency virus) in care. This strategy significantly increases the likelihood of achieving viral load suppression, improving health outcomes for patients and the community.

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Area of Science:

  • Public Health
  • Infectious Disease Management
  • Health Services Research

Background:

  • Optimizing treatment for human immunodeficiency virus (HIV) infection is crucial for individual and community health.
  • Health department HIV surveillance data linked with Medicaid managed care rosters can identify individuals with HIV who are not engaged in care or have unsuppressed viral loads.
  • MetroPlus Health Plan, a Medicaid managed care organization, implemented targeted interventions to address these gaps.

Purpose of the Study:

  • To evaluate the effectiveness of a 2-pronged approach involving street outreach and peer care connection interventions for optimizing HIV treatment.
  • To identify and re-engage individuals with HIV infection who have unsuppressed viral loads or are unengaged in care.

Main Methods:

  • A cohort study design was employed, collecting data on demographics, program contact type and frequency, antiretroviral therapy refill patterns, and HIV viral load and CD4 count.
  • Members identified as not engaged in care (no viral load test in 9 months) received outreach.
  • Members with unsuppressed viral loads received intensified care coordination and peer support.

Main Results:

  • Out of 1429 targeted members, 82% were still enrolled in the plan.
  • Street outreach achieved a 60% contact rate, while care coordination and peer support combined reached 40%.
  • Contacted members showed a 44% viral load suppression rate (<200 copies/mL) and had a significantly greater likelihood of achieving viral load suppression (OR, 1.55; P <.01).

Conclusions:

  • HIV surveillance data effectively targeted HIV-positive Medicaid members who were unsuppressed or disengaged.
  • Intensified outreach, care coordination, and peer support facilitated by a Medicaid managed care plan can lead to viral load suppression in individuals with HIV.