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Shift Work and Leukocyte Count Changes among Workers in Bangkok.
Nitt Hanprathet1, Somrat Lertmaharit1, Vitool Lohsoonthorn1,2
1Department of Preventive and Social Medicine, Faculty of Medicine, Chulalongkorn University, Pathumwan, Bangkok, Thailand.
Annals of Work Exposures and Health
|June 19, 2019
Summary
Shift work is linked to higher leukocyte counts, particularly basophils, eosinophils, and lymphocytes. This association was reversible, suggesting potential implications for chronic disease risk.
Area of Science:
- Occupational Health
- Immunology
- Epidemiology
Background:
- Cross-sectional studies suggest a link between shift work and elevated leukocyte counts.
- Previous evidence is limited in establishing causality due to study design.
Purpose of the Study:
- To longitudinally assess the association between shift work and leukocyte counts.
- To compare baseline leukocyte counts between shift and day workers.
- To examine trends in leukocyte counts over time in shift workers.
Main Methods:
- Retrospective cohort study of 6737 workers in Bangkok (2005-2016).
- Shift work exposure categorized (day, former, current).
- Annual leukocyte counts analyzed using multiple linear regression and multilevel analysis.
Main Results:
- Current shift work correlated with increased leukocyte counts (basophils, eosinophils, lymphocytes).
- Association was observed both cross-sectionally and longitudinally.
- Leukocyte count differences diminished over work years, indicating reversibility.
Conclusions:
- Shift work is associated with reversible increases in leukocyte counts.
- Further research is needed to determine if this impacts immune activity and chronic disease risk.
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