Related Experiment Video

Updated: Jan 23, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.7K

Epigenetics and vascular diseases

Matthew S Stratton1, Floriana Maria Farina2, Leonardo Elia3

  • 1Department of Physiology and Cell Biology, Ohio State University, Columbus, OH 43210, United States of America.

Journal of Molecular and Cellular Cardiology
|June 19, 2019
PubMed

Insights

Epigenetic mechanisms, including DNA methylation, histone modification, and non-coding RNAs, offer new therapeutic targets for cardiovascular diseases. Understanding these epigenetic changes is crucial for developing effective treatments for this leading cause of death.

Area of Science:

  • Cardiovascular Science
  • Epigenetics
  • Molecular Biology

Background:

  • Cardiovascular disease is a leading global cause of mortality and morbidity.
  • Current therapeutic strategies have limitations, necessitating novel approaches.
  • Epigenetic mechanisms are increasingly recognized for their role in vascular health and disease.

Purpose of the Study:

  • To provide an overview of epigenetic mechanisms.
  • To review recent findings on epigenetics in vascular diseases.
  • To highlight potential therapeutic targets within epigenetic pathways.

Main Methods:

  • Review of current literature on epigenetics and cardiovascular disease.
  • Analysis of classical epigenetic mechanisms (DNA methylation, histone modification).
  • Examination of non-coding RNA-mediated epigenetic regulation in vasculature.

Main Results:

  • Epigenetic modifications play a significant role in the development of vascular diseases.
  • DNA methylation and histone modifications are key classical epigenetic regulators.
  • Non-coding RNAs represent a novel class of epigenetic mediators in vascular processes.

Conclusions:

  • Epigenetics offers promising avenues for novel therapeutic strategies in cardiovascular disease.
  • Targeting epigenetic mechanisms could lead to more effective treatments.
  • Further research into non-coding RNAs in vascular epigenetics is warranted.

Keywords:
Cardiovascular diseasesDNA methylationHistone modificationsLong non-coding RNAsmicroRNAs

More Related Videos

Orthotopic Aortic Transplantation in Mice for the Study of Vascular Disease09:06

Orthotopic Aortic Transplantation in Mice for the Study of Vascular Disease

Published on: November 28, 2012

11.4K
Precision Ultrasound-guided Stem Cell Delivery for Vascular Repair in Aortic Diseases04:59

Precision Ultrasound-guided Stem Cell Delivery for Vascular Repair in Aortic Diseases

Published on: June 20, 2025

768

Related Concept Videos

Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
33.5K
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
3.7K
Seedless Vascular Plants03:24

Seedless Vascular Plants

Seedless Vascular Plants Were the First Tall Plants on Earth
66.7K
Vascular Spasm01:16

Vascular Spasm

The vascular phase, also known as vasospasm, is the initial stage of hemostasis, crucial for preventing excessive bleeding when a blood vessel is injured. After a vessel is cut, nerves in the damaged area trigger pain and other sensory impulses. Simultaneously, the smooth muscles in the vessel wall contract, resulting in a vascular spasm. This contraction reduces the vessel's diameter at the injury site, slowing or stopping blood loss through the vessel wall. Vascular spasms typically last...
3.4K
Vascular Resistance01:20

Vascular Resistance

Vascular resistance is a critical concept in understanding blood flow dynamics in the circulatory system. It refers to the resistance that blood encounters as it flows through the blood vessels. This resistance is a key factor in determining blood pressure and cardiac workload.
The primary determinants of vascular resistance are vessel diameter, blood viscosity, and vessel length. Among these, vessel diameter plays the most significant role due to the fourth power relationship described by...
10.3K
Overview of the Vascular System01:20

Overview of the Vascular System

The vascular system comprises an extensive network of arteries, capillaries, and veins. The vascular system can be broadly divided into the blood and lymphatic systems. Typically, blood vessels can be categorized into three histological regions: tunica intima, tunica media, and tunica adventitia. The tunica intima consists of a single layer of endothelial cells attached to the basal lamina. Underlying the basal lamina is a connective tissue layer and an elastic lamina that gives stability and...
3.4K