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Drug-induced endocrine blood pressure elevation
Katharina R Beck1, George R Thompson2, Alex Odermatt1
1Swiss Centre for Applied Human Toxicology and Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.
Pharmacological Research
|June 19, 2019
Summary
Uncontrolled hypertension poses cardiovascular risks. This review examines medications, supplements, and agents that can cause secondary hypertension by impacting the endocrine and catecholaminergic systems, offering therapeutic insights.
Area of Science:
- Endocrinology
- Pharmacology
- Cardiovascular Medicine
Background:
- Uncontrolled hypertension increases cardiovascular complication risk.
- Secondary hypertension, caused by identifiable factors, is often overlooked.
- Medications, herbal supplements, and OTC agents can cause secondary hypertension.
Purpose of the Study:
- To review drugs affecting blood pressure via endocrine pathways (steroid synthesis/metabolism, mineralocorticoid receptor) and the catecholaminergic system.
- To discuss drugs with known adverse effects, drug candidates, and withdrawn medications.
- To explore potential therapeutic strategies for drug-induced hypertension.
Main Methods:
- Literature review of drugs impacting blood pressure.
- Focus on endocrine and catecholaminergic system interactions.
- Analysis of drugs with known adverse effects, candidates, and withdrawals.
Main Results:
- Identified drug classes impacting blood pressure through endocrine and catecholaminergic mechanisms.
- Cataloged drugs with potential to cause secondary hypertension.
- Highlighted the importance of medication review in hypertension management.
Conclusions:
- Medications and supplements are significant, often overlooked, causes of secondary hypertension.
- Understanding drug-induced endocrine and catecholaminergic effects is crucial for diagnosis and treatment.
- Therapeutic strategies should consider the impact of various agents on blood pressure regulation.
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