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Updated: Jan 23, 2026

Acute Myocardial Infarction in Rats
Published on: February 16, 2011
Acute myocardial infarction in a patient with active actinic rectitis bleeding: Between the sword and the wall
Valdano Manuel1, Samuel P Steffen1,2, Fábio A Gaiotto1
1Division of Cardiovascular Surgery, Heart Institute (InCor), Hospital das Clínicas da Faculdade de Medicina, Universidade de São Paulo, Pinheiros, São Paulo, Brazil.
Insights
Coronary artery bypass graft (CABG) surgery can be performed without systemic heparin therapy in select patients with active bleeding. This approach safely managed a patient with unstable angina and gastrointestinal bleeding.
Area of Science:
- Cardiology
- Vascular Surgery
- Oncology
Background:
- Coronary artery bypass graft (CABG) is a common surgical procedure.
- Managing patients with concurrent cardiovascular disease and active bleeding presents significant clinical challenges.
- Actinic rectitis following prostate cancer radiation therapy can cause severe gastrointestinal bleeding.
Observation:
- A 79-year-old male presented with unstable angina and active lower gastrointestinal bleeding.
- The patient had undergone radiation therapy for prostate carcinoma one year prior, resulting in actinic rectitis.
- Coronary angiography revealed significant stenosis in the left anterior descending artery.
Findings:
- Standard antiplatelet or heparin therapies for coronary artery disease were contraindicated due to active rectal bleeding.
- Off-pump CABG was successfully performed without the use of systemic heparin.
- The patient experienced a favorable recovery following the procedure.
Implications:
- CABG without systemic heparin is a viable and safe option for carefully selected patients with active bleeding complications.
- This case highlights the importance of tailored surgical strategies in complex cardiovascular cases.
- Further research may explore the expanded indications and safety profiles of heparin-free CABG in bleeding patients.
Abstract:
A The coronary artery bypass graft (CABG) is common. Sometimes can be challenging. Here we present a 79-year-old man presented with unstable angina and simultaneous activelower gastrointestinal bleeding (hemoglobin level, 5.1 g/L) due to actinic rectitis after radiation therapy for prostate carcinoma performed 1 year previously. Coronary angiography showed marked stenosis of the left anterior descending artery. Antiplatelet aggregation therapy, such as percutaneous coronary intervention or systemic heparin therapy for coronary artery bypass, was not feasible owing to the active rectal bleeding. Therefore, off-pump CABG has performed without systemic heparin therapy and the patient recovered well. For specific cases, CABG without systemic heparin therapy can be safely performed.
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