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Updated: Jan 23, 2026

Evaluation of the Spatial Distribution of γH2AX following Ionizing Radiation
Published on: August 7, 2010
First-passage-time distribution in a moving parabolic potential with spatial roughness.
Yongge Li1, Yong Xu2,3, Jürgen Kurths4,5
1Center for Mathematical Sciences & School of Mathematics and Statistics, Huazhong University of Science and Technology, Wuhan 430074, China.
We introduce two methods, Kramers approximations (KA) and probability asymptotic approximation (PAA), to study first-passage-time distribution (FPTD) in rough potentials. PAA offers a more accurate and broadly applicable solution than KA, especially for large external forces.
Area of Science:
- Statistical Physics
- Nonlinear Dynamics
- Computational Physics
Background:
- First-passage-time distribution (FPTD) is crucial in various physical processes.
- Rough potentials introduce complexities not fully captured by standard theories.
- Existing methods like Kramers theory have limitations in certain parameter regimes.
Purpose of the Study:
- To investigate FPTD in time-dependent parabolic potentials with roughness.
- To compare the efficacy of Kramers theory and a novel integral equation-based method.
- To develop an improved analytical approach for FPTD calculations.
Main Methods:
- Spatially averaging rough potentials to derive effective smooth potentials and diffusion coefficients.
- Applying Kramers theory to obtain Kramers approximations (KAs) for FPTD.
- Developing and applying a probability asymptotic approximation (PAA) using an integral equation and transient PDF.
Main Results:
- Kramers approximations (KA) are accurate for high barriers and small forces but limited otherwise.
- The proposed probability asymptotic approximation (PAA) accurately predicts FPTD even for large external forces and low barriers.
- PAA shows good agreement with numerical simulations for rough potentials and low barriers.
- PAA extends the applicability to ultrafast varying potentials and short exiting times.
Conclusions:
- KA and PAA are complementary methods for determining FPTD across various barrier heights and external forces.
- PAA provides a significant analytical extension to KA, particularly for challenging parameter ranges.
- PAA is effective for mean first-passage time (MFPT) calculations across almost all external forces, unlike KA.
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