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Updated: Jan 23, 2026

Reusable Single Cell for Iterative Epigenomic Analyses
Published on: February 11, 2022
Cyclic annealing as an iterated random map
Muhittin Mungan1, Thomas A Witten2
1Institut für angewandte Mathematik, Universität Bonn, Endenicher Allee 60, 53115 Bonn, Germany.
Abstract:
Disordered magnets, martensitic mixed crystals, and glassy solids can be irreversibly deformed by subjecting them to external deformation. The deformation produces a smooth, reversible response punctuated by abrupt relaxation "glitches." Under appropriate repeated forward and reverse deformation producing multiple glitches, a strict repetition of a single sequence of microscopic configurations often emerges. We exhibit these features by describing the evolution of the system configuration from glitch to glitch as a mapping of N states into one another. A map U controls forward deformation; a second map D controls reverse deformation. Iteration of a given sequence of forward and reverse maps, e.g., DDDDUUUU necessarily produces a convergence to a fixed cyclic repetition of states covering multiple glitches. The repetition may have a period of more than one strain cycle, as recently observed in simulations. Using numerical sampling, we characterize the convergence properties of four types of random maps implementing successive physical restrictions. The most restrictive is the much-studied Preisach model. These maps show only the most qualitative resemblance to annealing simulations. However, they suggest further properties needed for a realistic mapping scheme.
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