Related Experiment Video
Updated: Jan 23, 2026
08:17
Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy
Published on: June 7, 2015
16.2K
Dynamics of tinnitus and coordinated reset therapy
Zachary Jackson1, Kurt Wiesenfeld1
1School of Physics, Georgia Institute of Technology, Atlanta 30332, Georgia, USA.
Physical Review. E
|June 20, 2019
Summary
A new dynamical model explores tinnitus onset and coordinated reset therapy. Numerical simulations show the model
Area of Science:
- Neuroscience
- Biophysics
- Computational Biology
Background:
- Tinnitus is a prevalent auditory disorder characterized by phantom sound perception.
- Current understanding of tinnitus mechanisms, particularly the role of outer hair cell (OHC) dynamics, is incomplete.
- Noninvasive therapies show promise but require theoretical frameworks for optimization.
Purpose of the Study:
- To develop a dynamical model of tinnitus onset incorporating mutual OHC interactions.
- To investigate the efficacy of coordinated reset (CR) therapy using this model.
- To elucidate the mechanisms by which sustained neural activity may impede natural auditory recovery.
Main Methods:
- Extended an existing OHC dynamics theory to include inter-cell coupling.
- Developed a computational model simulating tinnitus and CR therapy effects.
- Performed numerical simulations to analyze model behavior under various conditions.
Main Results:
- The model replicates key aspects of tinnitus onset, including the inhibition of natural recovery.
- Simulations demonstrate that the model's behavior aligns with findings from a clinical study on CR therapy.
- The model provides insights into how sustained neural activity contributes to tinnitus pathology.
Conclusions:
- The developed dynamical model offers a valuable tool for understanding tinnitus pathophysiology.
- The model supports the potential of coordinated reset therapy for tinnitus management.
- Further research using this model can refine therapeutic strategies and explore underlying neural mechanisms.
Related Concept Videos
02:57Coordination Number and Geometry
19.0K
For transition metal complexes, the coordination number determines the geometry around the central metal ion. Table 1 compares coordination numbers to molecular geometry. The most common structures of the complexes in coordination compounds are octahedral, tetrahedral, and square planar.
19.0K
02:54Coordination Compounds and Nomenclature
26.4K
In most main group element compounds, the valence electrons of the isolated atoms combine to form chemical bonds that satisfy the octet rule. For instance, the four valence electrons of carbon overlap with electrons from four hydrogen atoms to form CH4. The one valence electron leaves sodium and adds to the seven valence electrons of chlorine to form the ionic formula unit NaCl (Figure 1a). Transition metals do not normally bond in this fashion. They primarily form coordinate covalent bonds, a...
26.4K
02:33Lattice Centering and Coordination Number
11.4K
The structure of a crystalline solid, whether a metal or not, is best described by considering its simplest repeating unit, which is referred to as its unit cell. The unit cell consists of lattice points that represent the locations of atoms or ions. The entire structure then consists of this unit cell repeating in three dimensions. The three different types of unit cells present in the cubic lattice are illustrated in Figure 1.
Types of Unit Cells
Imagine taking a large number of identical...
Types of Unit Cells
Imagine taking a large number of identical...
11.4K
01:21Equations of Motion: Rectangular Coordinates and Cylindrical Coordinates
748
Understanding the motion of particles is a fundamental aspect of classical mechanics, and the choice of the coordinate system plays a pivotal role in unraveling the complexities of their dynamics.
When a particle moves relative to an inertial frame, the equations of motion can be expressed using rectangular components. If the motion is confined to the x-y plane, the equations having the x and y coordinates only can be used to simplify the mathematical representation.
However, when particles...
When a particle moves relative to an inertial frame, the equations of motion can be expressed using rectangular components. If the motion is confined to the x-y plane, the equations having the x and y coordinates only can be used to simplify the mathematical representation.
However, when particles...
748
01:23Spherical Coordinates
15.0K
Spherical coordinate systems are preferred over Cartesian, polar, or cylindrical coordinates for systems with spherical symmetry. For example, to describe the surface of a sphere, Cartesian coordinates require all three coordinates. On the other hand, the spherical coordinate system requires only one parameter: the sphere's radius. As a result, the complicated mathematical calculations become simple. Spherical coordinates are used in science and engineering applications like electric and...
15.0K
01:23Insulation Coordination
559
Insulation coordination is the process of matching electric equipment's insulation strength with protective device characteristics to protect the equipment against expected overvoltages. This selection is based on engineering judgment and cost. Equipment can generally withstand short-duration high transient overvoltages, but repeated tests with identical waveforms can yield inconsistent results. As a result, standard impulse voltage waveforms are used for testing, defined by specific times...
559