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Simple mechanics of protein machines
Holger Flechsig1, Alexander S Mikhailov1,2
11 Nano Life Science Institute (WPI-NanoLSI), Kanazawa University , Kakuma-machi, 920-1192 Kanazawa , Japan.
Abstract:
While belonging to the nanoscale, protein machines are so complex that tracing even a small fraction of their cycle requires weeks of calculations on supercomputers. Surprisingly, many aspects of their operation can be however already reproduced by using very simple mechanical models of elastic networks. The analysis suggests that, similar to other self-organized complex systems, functional collective dynamics in such proteins is effectively reduced to a low-dimensional attractive manifold.
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