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Predictive Immune Modeling of Solid Tumors
Published on: February 25, 2020
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NEDD9 overexpression predicts poor prognosis in solid cancers: a meta-analysis.
Yang Gu1, Jingjing Lu2, Chen Chen3
1Department of Orthopedics, The Affiliated Union Hospital of Fujian Medical University, Fuzhou, People's Republic of China.
Oncotargets and Therapy
|June 20, 2019
Summary
Overexpression of neural precursor cell-expressed developmentally down-regulated 9 (NEDD9) is linked to poorer survival outcomes in patients with solid tumors. This finding suggests NEDD9 may serve as a prognostic biomarker for cancer patients.
Area of Science:
- Oncology
- Molecular Biology
- Biomarker Discovery
Background:
- Neural precursor cell-expressed developmentally down-regulated 9 (NEDD9) is implicated in cancer development.
- The prognostic significance of NEDD9 in solid tumors is not fully established.
- Existing evidence on NEDD9's role in cancer prognosis is conflicting.
Purpose of the Study:
- To conduct a meta-analysis evaluating the association between NEDD9 expression and survival rates in solid tumors.
- To clarify the prognostic value of NEDD9 in various solid cancer types.
- To determine if NEDD9 overexpression predicts poor prognosis in solid cancer patients.
Main Methods:
- Systematic literature search across multiple databases.
- Inclusion and exclusion criteria applied to select relevant studies.
- Meta-analysis of pooled Hazard Ratios (HRs) for overall survival (OS) and disease-free survival (DFS)/progression-free survival (PFS)/recurrence-free survival (RFS)/cancer-specific survival (CSS).
- Assessment of heterogeneity and publication bias.
Main Results:
- Eighteen studies comprising 2,476 patients were analyzed.
- NEDD9 overexpression was significantly associated with poorer overall survival (HR=1.82; 95% CI: 1.43-2.31).
- NEDD9 overexpression was also linked to worse DFS/PFS/RFS/CSS (HR=2.54; 95% CI: 1.93-3.33).
Conclusions:
- NEDD9 overexpression is a potential predictive marker for adverse outcomes in solid cancer patients.
- The findings support NEDD9 as a prognostic biomarker in oncology.
- Further research may validate NEDD9 for clinical application in cancer prognosis.
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