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LncRNA FENDRR attenuates colon cancer progression by repression of SOX4 protein

Jianchao Liu1, Wenfeng Du1

  • 1Department of Gastroenterological Surgery, Liaocheng People's Hospital, Liaocheng Clinical School of Taishan Medical University, Liaocheng, Shandong Province, 252000, People's Republic of China.

Oncotargets and Therapy
|June 20, 2019
PubMed

Insights

FENDRR, a long noncoding RNA, is frequently reduced in colon cancer. Lower FENDRR levels correlate with advanced stages and poor prognosis, suggesting its tumor-suppressive role.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Long noncoding RNAs (lncRNAs) play critical roles in gene regulation.
  • FENDRR (Homo sapiens FOXF1 adjacent noncoding developmental regulatory RNA) is a novel lncRNA involved in transcriptional and post-transcriptional regulation.
  • The role of FENDRR in colon cancer remains largely unexplored.

Purpose of the Study:

  • To investigate the function and clinical significance of FENDRR in colon cancer.
  • To determine FENDRR's impact on colon cancer cell behavior and progression.
  • To elucidate the molecular mechanism underlying FENDRR's action in colon cancer.

Main Methods:

  • Analysis of FENDRR expression in colon cancer tissues and cell lines.
  • Cellular assays including CCK-8, invasion assays, and epithelial-mesenchymal transition (EMT) assessment.
  • Molecular techniques such as Western blot, immunohistochemistry, and confocal immunofluorescence.
  • In vitro and in vivo animal studies to validate findings.
  • Investigation of FENDRR's interaction with SOX4 protein.

Main Results:

  • FENDRR expression is significantly attenuated in colon cancer tissues and cell lines compared to normal controls.
  • Low FENDRR levels are associated with advanced clinical stages and predict poor patient prognosis.
  • Re-expression of FENDRR inhibits colon cancer cell viability, invasion, and EMT.
  • FENDRR modulates SOX4 protein expression, impacting colon cancer progression.
  • In vitro and in vivo experiments confirm FENDRR's regulatory role in colon cancer.

Conclusions:

  • FENDRR acts as a tumor suppressor in colon cancer by inhibiting SOX4.
  • FENDRR downregulation is a significant event in colon cancer development and progression.
  • FENDRR represents a potential therapeutic target for colon cancer treatment.
Keywords:
FENDRRSOX4colon cancerprogression

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