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Biomarkers in Inflammatory Myopathies-An Expanded Definition
Olivier Benveniste1, Hans-Hilmar Goebel2,3, Werner Stenzel2
1Department of Internal Medicine and Clinical Immunology, Pitié-Salpêtrière University Hospital, Assistance Public-Hôpitaux de Paris, Sorbonne-Université, INSERM, UMR974, Paris, France.
Frontiers in Neurology
|June 20, 2019
Summary
Biomarkers are crucial for diagnosing and treating inflammatory myopathies, but current evidence for their routine use is limited. Further research is needed to validate these biological markers in larger patient cohorts.
Area of Science:
- Biomedical Research
- Pathophysiology
- Inflammatory Myopathies
Background:
- Biomarkers offer critical insights into pathophysiological conditions, particularly for inflammatory myopathies.
- They are essential for addressing diagnostic, prognostic, and therapeutic questions in clinical practice.
Purpose of the Study:
- To review the relevance of biomarkers in inflammatory myopathies, focusing on myopathological features.
- To assess the current level of evidence for routine biomarker use in daily clinical practice.
Main Methods:
- Review of existing literature on biomarkers in inflammatory myopathies.
- Analysis of myopathological features associated with biomarker relevance.
- Evaluation of the current evidence base for biomarker validation.
Main Results:
- The level of evidence for routine biomarker use in inflammatory myopathies is currently low.
- Few biomarkers have been validated in large patient cohorts or independent biopsy series.
- Biomarker evaluation is an ongoing process due to incomplete understanding of myositis pathophysiology.
Conclusions:
- Current biomarkers for inflammatory myopathies should be considered expert opinions rather than definitive tools.
- Expansion of the definition and validation of biomarkers for myositis is an emerging and important field.
- Further research is required to establish robust, validated biomarkers for clinical application.
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