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Quetiapine as treatment for delirium in critically ill children: A case series

Chani Traube1, Robert Witcher2, Elena Mendez-Rico2

  • 1Department of Pediatric Critical Care Medicine, Weill Cornell Medical College, New York, NY, USA.

Journal of Pediatric Intensive Care
|June 20, 2019
PubMed

Insights

Quetiapine shows promise for treating delirium in critically ill children. This case series found that four pediatric patients experienced rapid improvement in delirium symptoms within 24 hours of starting quetiapine.

Area of Science:

  • Pediatric critical care medicine
  • Neuroscience
  • Pharmacology

Background:

  • Delirium is common in critically ill children, potentially worsening outcomes.
  • Early pharmacological intervention for pediatric delirium may be beneficial.

Purpose of the Study:

  • To evaluate the efficacy of quetiapine in treating delirium in critically ill children.
  • To assess the safety and effectiveness of quetiapine for pediatric delirium.

Main Methods:

  • A case series of four critically ill children (8 months to 14 years) with delirium.
  • Administration of quetiapine for delirium treatment.

Main Results:

  • All four patients showed improvement in delirium symptoms within 24 hours of quetiapine initiation.
  • Quetiapine was associated with rapid symptom resolution in pediatric delirium.

Conclusions:

  • Quetiapine may be a viable therapeutic option for delirium in critically ill children.
  • Further prospective, blinded studies are warranted to confirm quetiapine's efficacy and safety in pediatric delirium.

Keywords:
Deliriumcritical carepediatricsquetiapinetreatment

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