Related Experiment Video

Updated: Jan 23, 2026

High-throughput Flow Cytometry Cell-based Assay to Detect Antibodies to N-Methyl-D-aspartate Receptor or Dopamine-2 Receptor in Human Serum
10:19

High-throughput Flow Cytometry Cell-based Assay to Detect Antibodies to N-Methyl-D-aspartate Receptor or Dopamine-2 Receptor in Human Serum

Published on: November 23, 2013

16.8K

Use of dexmedetomidine as adjunctive therapy for anti-N-methyl-D-aspartate receptor encephalitis

Christopher J Babbitt1, Jean Lake1, Glenn K Levine1

  • 1Pediatric Critical Care, Miller's Children Hospital, Long California, CA, USA.

Journal of Pediatric Intensive Care
|June 20, 2019
PubMed

Insights

Anti-N-methyl-D-aspartate receptor encephalitis, a condition affecting children, presents severe neurological symptoms. This report details the successful use of dexmedetomidine for acute treatment, offering a potential new therapeutic option.

Area of Science:

  • Neurology
  • Pediatrics
  • Pharmacology

Background:

  • Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is increasingly diagnosed in pediatric patients.
  • The condition necessitates intensive care due to severe central nervous system manifestations.

Observation:

  • Patients exhibit agitation, abnormal movements, hypoventilation, seizures, and autonomic instability.
  • Current treatment guidelines lack consensus for acute symptom management.

Findings:

  • This case report introduces dexmedetomidine as a novel therapeutic agent for anti-NMDAR encephalitis.
  • Dexmedetomidine effectively managed the acute neurological symptoms in the presented pediatric case.

Implications:

  • Dexmedetomidine shows promise as a safe and effective option for managing anti-NMDAR encephalitis in children.
  • Further research is warranted to establish dexmedetomidine's role in clinical practice for this condition.

Keywords:
Dexmedetomidineanti-N-methyl-D-aspartate receptorencephalitisseizures

More Related Videos

A Simple Cell-based Immunofluorescence Assay to Detect Autoantibody Against the N-Methyl-D-Aspartate NMDA Receptor in Blood07:20

A Simple Cell-based Immunofluorescence Assay to Detect Autoantibody Against the N-Methyl-D-Aspartate NMDA Receptor in Blood

Published on: January 9, 2018

10.3K
Adjunctive Diode Laser Therapy and Probiotic Lactobacillus Therapy in the Treatment of Periodontitis and Peri-Implant Disease06:06

Adjunctive Diode Laser Therapy and Probiotic Lactobacillus Therapy in the Treatment of Periodontitis and Peri-Implant Disease

Published on: May 9, 2022

3.1K

Related Concept Videos

Heart Failure VI: Adjunct Therapies01:22

Heart Failure VI: Adjunct Therapies

Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
280
Internal Receptors01:31

Internal Receptors

Many cellular signals are hydrophilic and therefore cannot pass through the plasma membrane. However, small or hydrophobic signaling molecules can cross the hydrophobic core of the plasma membrane and bind to internal, or intracellular, receptors that reside within the cell. Many mammalian steroid hormones use this mechanism of cell signaling, as does nitric oxide (NO) gas.
74.3K
Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.4K
Receptor-mediated Endocytosis01:39

Receptor-mediated Endocytosis

Overview
110.7K
Enzyme-linked Receptors01:00

Enzyme-linked Receptors

Enzyme-linked receptors are proteins that act as both receptor and enzyme, activating multiple intracellular signals. This is a large group of receptors that include the receptor tyrosine kinase (RTK) family. Many growth factors and hormones bind to and activate the RTKs.
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
86.3K
G-protein Coupled Receptors01:21

G-protein Coupled Receptors

G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.
131.7K