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Recent Advances in Understanding FOXN3 in Breast Cancer, and Other Malignancies

Xiangyi Kong1, Jie Zhai1, Chengrui Yan2

  • 1Department of Breast Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Frontiers in Oncology
|June 20, 2019
PubMed

Insights

Forkhead box N3 (FOXN3) is a tumor suppressor protein. Its function in breast cancer is largely unknown but may be critical for understanding tumorigenesis and developing new therapies.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • The forkhead box (FOX) protein family plays crucial roles in cellular functions.
  • FOXN3, also known as CHES1, exhibits transcriptional inhibitory activity.
  • Alterations in FOXN3 are implicated in various cancers, including melanoma and hepatocellular carcinoma.

Purpose of the Study:

  • To review the known functions of FOXN3.
  • To explore the known and potential roles of FOXN3 in breast cancer.

Main Methods:

  • Literature review of FOXN3 functions.
  • Analysis of existing cancer research focusing on FOXN3.

Main Results:

  • FOXN3 is a known tumor suppressor involved in cell cycle regulation.
  • Its specific role in breast cancer pathogenesis is not well-defined.
  • FOXN3 alterations are observed in several cancer types.

Conclusions:

  • Further research is needed to elucidate FOXN3's function in breast cancer.
  • Understanding FOXN3's role could offer new therapeutic targets for breast cancer treatment.
Keywords:
FOXN3breastcancerforkheadfunctionmalignancyregulationreview

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