Related Experiment Video

Updated: Jan 23, 2026

Assessing Endothelial Vasodilator Function with the Endo-PAT 2000
07:46

Assessing Endothelial Vasodilator Function with the Endo-PAT 2000

Published on: October 15, 2010

44.4K

Endothelial function and dysfunction in the cardiovascular system: the long non-coding road

João P Monteiro1, Matthew Bennett1, Julie Rodor1

  • 1Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh, UK.

Cardiovascular Research
|June 20, 2019
PubMed

Insights

Long non-coding RNAs (lncRNAs) are key regulators of endothelial cell function in cardiovascular health and disease. This review explores their role in blood vessel biology and potential as therapeutic targets.

Area of Science:

  • Cardiovascular Biology
  • Molecular Medicine
  • Genomics

Background:

  • Endothelial cells (ECs) are crucial for vascular function and cardiovascular disease pathogenesis.
  • Understanding EC molecular regulation is vital for clinical advancements.
  • Long non-coding RNAs (lncRNAs) are emerging as critical regulators of ECs.

Purpose of the Study:

  • To review the role of lncRNAs in endothelial biology during cardiovascular development, homeostasis, and disease.
  • To highlight challenges and solutions in lncRNA discovery and characterization.
  • To discuss the therapeutic potential and challenges of targeting lncRNAs in cardiovascular disease.

Main Methods:

  • Literature review of studies on lncRNAs and endothelial cells.
  • Analysis of lncRNA functions in cardiovascular contexts.
  • Discussion of translational implications and therapeutic strategies.

Main Results:

  • lncRNAs actively regulate the endothelial transcriptome and function.
  • Specific lncRNAs are implicated in endothelial phenotypes relevant to cardiovascular disease.
  • Overcoming discovery and characterization challenges has advanced the field.

Conclusions:

  • lncRNAs offer novel insights into EC contributions to cardiovascular pathology.
  • Targeting lncRNAs presents emerging therapeutic opportunities for cardiovascular diseases.
  • Further research is needed to fully realize the translational potential of lncRNAs.

Keywords:
Endothelial functionEndothelial heterogeneityLncRNA mechanismLong non-coding RNARNA-sequencing

More Related Videos

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause06:18

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause

Published on: August 13, 2019

12.8K
Author Spotlight: Exercise Test for Evaluation of the Functional Efficacy of the Pig Cardiovascular System02:47

Author Spotlight: Exercise Test for Evaluation of the Functional Efficacy of the Pig Cardiovascular System

Published on: May 12, 2023

2.0K

Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.8K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

3.6K
Design Example: Alignment of a Road Line Using GIS01:17

Design Example: Alignment of a Road Line Using GIS

The alignment of a road line using Geographic Information Systems (GIS) is a critical process in civil engineering, combining advanced technology with practical decision-making. This methodology begins with the collection of geospatial data, including information on land cover, geomorphology, drainage patterns, slope, and contour details. Such data is typically acquired through satellite imagery and GIS tools, offering a comprehensive understanding of the terrain.Once the data is gathered, it...
339
Nursing Code of Ethics01:29

Nursing Code of Ethics

The Nursing Code of Ethics sets the ethical benchmark for the profession, and guides nurses in ethical analysis and decision making at the societal, organizational, and clinical levels. The code encompasses showing compassion and respect for the patient, their families, and communities in all circumstances while committing to providing patient-centered care. In addition, the code states that nurses must advocate for the patient by defending a cause or recommendation to protect their rights,...
4.3K
Overview of the Cardiovascular System01:14

Overview of the Cardiovascular System

The cardiovascular system is a vital transportation system in the body. It comprises the heart and blood vessels and facilitates the exchange of gases, nutrients, and waste products.
Heart
The heart is the central pump of the cardiovascular system that circulates blood throughout the body. It comprises two atria receiving the blood and two ventricles pumping blood out of the heart. Their rhythmic contractions, called heartbeats, ensure that blood flow remains continuous.
Blood Vessels
Blood...
11.1K
Structural Protein Function01:56

Structural Protein Function

Structural proteins are a category of proteins responsible for functions ranging from cell shape and movement to providing support to major structures such as bones, cartilage, hair, and muscles. This group includes proteins such as collagen, actin, myosin, and keratin.
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity.  In bones and teeth, it mineralizes to...
29.8K