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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Endothelial function and dysfunction in the cardiovascular system: the long non-coding road.

João P Monteiro1, Matthew Bennett1, Julie Rodor1

  • 1Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh, UK.

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Summary
This summary is machine-generated.

Long non-coding RNAs (lncRNAs) are key regulators of endothelial cell function in cardiovascular health and disease. This review explores their role in blood vessel biology and potential as therapeutic targets.

Keywords:
Endothelial functionEndothelial heterogeneityLncRNA mechanismLong non-coding RNARNA-sequencing

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Area of Science:

  • Cardiovascular Biology
  • Molecular Medicine
  • Genomics

Background:

  • Endothelial cells (ECs) are crucial for vascular function and cardiovascular disease pathogenesis.
  • Understanding EC molecular regulation is vital for clinical advancements.
  • Long non-coding RNAs (lncRNAs) are emerging as critical regulators of ECs.

Purpose of the Study:

  • To review the role of lncRNAs in endothelial biology during cardiovascular development, homeostasis, and disease.
  • To highlight challenges and solutions in lncRNA discovery and characterization.
  • To discuss the therapeutic potential and challenges of targeting lncRNAs in cardiovascular disease.

Main Methods:

  • Literature review of studies on lncRNAs and endothelial cells.
  • Analysis of lncRNA functions in cardiovascular contexts.
  • Discussion of translational implications and therapeutic strategies.

Main Results:

  • lncRNAs actively regulate the endothelial transcriptome and function.
  • Specific lncRNAs are implicated in endothelial phenotypes relevant to cardiovascular disease.
  • Overcoming discovery and characterization challenges has advanced the field.

Conclusions:

  • lncRNAs offer novel insights into EC contributions to cardiovascular pathology.
  • Targeting lncRNAs presents emerging therapeutic opportunities for cardiovascular diseases.
  • Further research is needed to fully realize the translational potential of lncRNAs.