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Saving bones without risking brain-bisphosphonates and risk of stroke: matched case-control study
Z B Asghar1, A Godoy Caballero2, S Pathirannehelage3
1Mathematical Modelling and Statistics, Community and Health Research Unit, School of Health and Social Care, College of Social Science, University of Lincoln, Brayford Campus, Lincoln, LN6 7TS, UK. zasghar@lincoln.ac.uk.
This study found no link between bisphosphonate drugs and stroke risk. Analysis of a large patient dataset, considering many factors, confirmed no increased or decreased stroke risk for bisphosphonate users.
Area of Science:
- Clinical Medicine
- Pharmacology
- Epidemiology
Background:
- Conflicting evidence exists regarding bisphosphonate use and stroke risk.
- Previous studies have reported increased, decreased, or unchanged stroke risk associated with bisphosphonates.
- This study aimed to clarify the association using a large clinical dataset.
Purpose of the Study:
- To investigate the association between bisphosphonate treatment and the risk of stroke.
- To analyze a large routine clinical dataset to determine if bisphosphonates impact stroke risk.
- To provide clear evidence on the bisphosphonate-stroke relationship, addressing existing controversies.
Main Methods:
- A matched nested case-control study design was employed.
- Routinely collected electronic data from English primary care practices were analyzed.
- Conditional logistic regression adjusted for numerous confounders including demographics, cardiovascular risk factors, and socioeconomic status.
Main Results:
- The study included 31,414 stroke cases and an equal number of matched controls.
- Bisphosphonate treatment showed no statistically significant association with stroke risk (OR 0.86, 95% CI 0.62-1.19).
- This finding remained consistent after adjusting for a wide range of potential confounding factors.
Conclusions:
- No association was found between bisphosphonate treatment and the risk of stroke.
- The study's findings suggest that bisphosphonates do not increase or decrease stroke risk.
- Results were robust after comprehensive adjustment for clinical and demographic confounders.
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