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Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model
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[Osteoporosis and multimorbidity].

S Wicklein1, M Gosch2

  • 1Medizinische Klinik 2 - Schwerpunkt Geriatrie, Universitätsklinik für Geriatrie, Paracelsus Medizinische Privatuniversität, Campus Nürnberg, Prof.-Ernst-Nathan-Str. 1, 90419, Nürnberg, Deutschland. Susanne.wicklein@klinikum-nuernberg.de.

Zeitschrift Fur Gerontologie Und Geriatrie
|June 20, 2019
PubMed
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Osteoporosis in older adults is linked to multiple health conditions, increasing fracture risk. Managing this bone disease requires considering overall patient health and common geriatric issues like falls.

Area of Science:

  • Gerontology
  • Bone Metabolism
  • Geriatric Medicine

Background:

  • Osteoporosis is a systemic bone disease characterized by reduced bone strength and mass, leading to increased fracture risk, particularly in older patients.
  • An isolated approach to osteoporosis is insufficient in older adults due to the high prevalence of multimorbidity.
  • Osteoporosis is associated with various diseases through shared pathophysiology, risk factors, or medication side effects, and geriatric syndromes like falls are significant.
  • Geriatric syndromes, including falls, play a crucial role in the overall health of older patients with osteoporosis.

Purpose of the Study:

  • To provide an overview of the interactions between osteoporosis and multimorbidity in older adults.
  • To highlight the clinical management of osteoporosis considering multiple co-existing diseases in the elderly.
Keywords:
Accidental fallsBone densityComorbidityFractures, boneMedication

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  • To discuss the impact of common diseases in older age on osteoporosis and vice versa.

    • Main Methods:

    • Review of scientific literature on osteoporosis, multimorbidity, and geriatric syndromes.
    • Analysis of pathophysiological mechanisms and risk factors linking osteoporosis with common diseases in older age.
    • Presentation of clinical management strategies for osteoporosis in the context of multimorbidity.

    Main Results:

    • Multiple diseases share pathophysiological pathways or risk factors with osteoporosis.
    • Medications used for other conditions can negatively impact bone health.
    • Geriatric syndromes, especially falls, are highly prevalent and interact with osteoporosis.
    • Effective management requires a holistic approach addressing all comorbidities.

    Conclusions:

    • Managing osteoporosis in older adults necessitates a comprehensive strategy that integrates the treatment of co-existing conditions.
    • Understanding the interplay between osteoporosis and multimorbidity is essential for preventing fragility fractures.
    • Clinical practice should adopt a patient-centered approach, considering the full spectrum of health issues in elderly patients.