Left Ventricular Function and Cardiac Biomarker Release-The Influence of Exercise Intensity, Duration and Mode: A...

Area of Science:

• Cardiology
• Exercise Physiology
• Biomarkers

Background:

• Cardiac troponin (cTn) release and left ventricular (LV) function changes post-exercise are not fully understood.
• Existing literature exhibits significant heterogeneity and variability in exercise-induced cardiac function studies.

Purpose of the Study:

• To systematically review and meta-analyze exercise studies investigating the relationship between cTn and LV function.
• To identify study-level and exercise factors influencing cTn release and LV function variations.

Main Methods:

• Systematic search of major databases (PubMed Central, Science Direct, SPORTDISCUS, MEDLINE) for studies from 1997-2018.
• Inclusion of studies with >30 mins continuous exercise, measuring cTn, LV ejection fraction (LVEF), or E/A ratio.
• Random-effects meta-analyses and meta-regressions incorporating age, exercise heart rate (HR), duration, and mass as covariates.

Main Results:

• Pooled cTn event rates were observed in 45.6% of participants, though not statistically significant overall.
• Significant reductions in E/A ratio (-0.38) and LVEF (-2.02%) were noted pre- to post-exercise.
• Increased exercise HR predicted troponin release and E/A ratio changes; participant age was negatively associated with cTn release.

Conclusions:

• Exercise intensity and age are key determinants of cTn release.
• Exercise HR and cTn release impact LV diastolic function, suggesting high-intensity exercise can impair it.
• Future research should employ advanced echocardiography, standardize hydration, and conduct follow-up measurements to explore aging and training effects on cTn release and function.