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Small-Molecule CSF1R Inhibitors as Anticancer Agents.

Qiuju Xun1, Zhen Wang1, Xianglong Hu1

  • 1International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), School of Pharmacy, Jinan University, 601 Huangpu Avenue West, Guangzhou 510632, China.

Current Medicinal Chemistry
|June 20, 2019
PubMed
Summary

Tumor-Associated Macrophages (TAMs) drive cancer growth and suppress immunity. Inhibiting CSF1R kinase, which controls TAMs, shows promise for new cancer treatments, with several small molecule inhibitors in clinical trials.

Keywords:
CSF1RTumor-Associated Macrophages (TAMs)anticancer agentsclinical trialsinhibitorspharmacophore features.

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