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Self-microemulsifying Drug Delivery System for Problematic Molecules: An Update
Dilpreet Singh1, Ashok K Tiwary2, Neena Bedi1
1Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab 143005, India.
Recent Patents on Nanotechnology
|June 20, 2019
Summary
Self microemulsifying drug delivery systems (SMEDDS) enhance the bioavailability of poorly soluble drugs by improving physicochemical properties. Recent innovations show diverse SMEDDS formulations, including powders and tablets, with many gaining regulatory approval.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
- Nanotechnology
Background:
- Poor bioavailability of drug molecules often stems from high lipophilicity, low solubility, and extensive first-pass metabolism.
- Self-microemulsifying drug delivery systems (SMEDDS) are lipidic Type IV nano-formulations that can modify drug physicochemical properties.
Purpose of the Study:
- To review recent innovations (2012-2019) in self-emulsifying formulations for delivering challenging molecules.
- To detail the outcomes of research in this field for poorly soluble drugs, phytoconstituents, and peptides.
Main Methods:
- Comprehensive review of scientific literature and patents from 2012-2019.
- Analysis of various self-emulsifying formulation types and their applications.
Main Results:
- Development of diverse SMEDDS-derived formulations including powders, granules, tablets, pellets, eutectic, and cationic systems.
- Numerous research reports and patents filed, with several SMEDDS formulations achieving US-FDA approval.
Conclusions:
- SMEDDS demonstrate significant potential for enhancing the physicochemical properties of Active Pharmaceutical Ingredients (APIs).
- A wide array of formulation types can be derived from SMEDDS, improving API attributes and delivery efficacy.
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