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Related Concept Videos

Drug Delivery: Overview01:16

Drug Delivery: Overview

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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
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The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
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The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
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Drug Delivery: Miscellaneous Routes01:22

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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
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In multicellular organisms, many molecules transmit signals between cells to pass information. These signals vary in complexity and include small peptides, nucleotides, steroids, fatty acid derivatives, and dissolved gases such as nitric oxide. Some signaling molecules diffuse through the plasma membrane to act locally between neighboring cells or travel long distances. Others remain attached to the cell surface, transmitting information to other cells only when they make contact. In some...
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Self-microemulsifying Drug Delivery System for Problematic Molecules: An Update.

Dilpreet Singh1, Ashok K Tiwary2, Neena Bedi1

  • 1Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab 143005, India.

Recent Patents on Nanotechnology
|June 20, 2019
PubMed
Summary
This summary is machine-generated.

Self microemulsifying drug delivery systems (SMEDDS) enhance the bioavailability of poorly soluble drugs by improving physicochemical properties. Recent innovations show diverse SMEDDS formulations, including powders and tablets, with many gaining regulatory approval.

Keywords:
SMEDDSSolubility enhancementbioavailability enhancementpatentspeptidesphytoconstituentssupersaturation.

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Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery Systems
  • Nanotechnology

Background:

  • Poor bioavailability of drug molecules often stems from high lipophilicity, low solubility, and extensive first-pass metabolism.
  • Self-microemulsifying drug delivery systems (SMEDDS) are lipidic Type IV nano-formulations that can modify drug physicochemical properties.

Purpose of the Study:

  • To review recent innovations (2012-2019) in self-emulsifying formulations for delivering challenging molecules.
  • To detail the outcomes of research in this field for poorly soluble drugs, phytoconstituents, and peptides.

Main Methods:

  • Comprehensive review of scientific literature and patents from 2012-2019.
  • Analysis of various self-emulsifying formulation types and their applications.

Main Results:

  • Development of diverse SMEDDS-derived formulations including powders, granules, tablets, pellets, eutectic, and cationic systems.
  • Numerous research reports and patents filed, with several SMEDDS formulations achieving US-FDA approval.

Conclusions:

  • SMEDDS demonstrate significant potential for enhancing the physicochemical properties of Active Pharmaceutical Ingredients (APIs).
  • A wide array of formulation types can be derived from SMEDDS, improving API attributes and delivery efficacy.