Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genomics02:02

Genomics

39.8K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
39.8K
Translation01:31

Translation

155.9K
Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of...
155.9K
Plastic Deformations01:19

Plastic Deformations

442
Plastic deformation represents a fundamental concept in materials science, which explains the irreversible change in the shape of a material when it experiences stress beyond its elastic capability. This phenomenon is important in structural engineering, especially in designing and analyzing cantilever beams—structures that are securely fixed at one end and bear loads at the opposite end. When these beams are subjected to loads within their elastic range, they will return to their...
442
Plastic Deformations01:14

Plastic Deformations

412
It is essential to understand how structural members behave under plastic deformation when the bending stress exceeds the material's yield strength. This state of deformation permanently alters the shape of the member, in contrast to the linear elastic behavior observed before yielding. The strain at any point in the member is expressed in terms of maximum strain. Notably, the neutral axis, which coincides with the centroid during elastic bending, shifts away from the centroid under plastic...
412
Initiation of Translation02:33

Initiation of Translation

38.4K
Initiating translation is complex because it involves multiple molecules. Initiator tRNA, ribosomal subunits, and eukaryotic initiation factors (eIFs) are all required to assemble on the initiation codon of mRNA. This process consists of several steps that are mediated by different eIFs.
First, the initiator tRNA must be selected from the pool of elongator tRNAs by eukaryotic initiation factor 2 (eIF2). The initiator tRNA (Met-tRNAi) has conserved sequence elements including modified bases at...
38.4K
Termination of Translation01:44

Termination of Translation

27.5K
The large ribosomal subunit has several important structures essential to translation. These include the peptidyl transferase center (PTC) - which is the site where the peptide bond is formed - and a large, internal, water-filled tube through which the nascent polypeptide moves. This latter structure is called the Peptide Exit Tunnel, and it begins at the PTC and spans the body of the large ribosomal subunit. During translation, as the nascent polypeptide chain is synthesized, it passes through...
27.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

KLF6 activation marks an angiogenic and apoptosis resistant endothelial phenotype in pulmonary arterial hypertension.

Communications biology·2026
Same author

Long-term outcomes of congenital high airway obstruction syndrome (CHAOS) at a single comprehensive fetal center.

Fetal diagnosis and therapy·2026
Same author

Cell fate specification during respiratory development requires ARID1A-containing canonical BAF complex activity.

Nature communications·2026
Same author

The burden of autoimmune pulmonary alveolar proteinosis: a systematic review.

European respiratory review : an official journal of the European Respiratory Society·2026
Same author

Impact of Benign Bilateral Vocal Fold Lesions Across Childhood: Does Age Matter?

Journal of voice : official journal of the Voice Foundation·2026
Same author

Divergent pathways of surfactant protein C maturation for disease-associated isoforms.

The Journal of biological chemistry·2026

Related Experiment Video

Updated: Jan 23, 2026

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes
09:10

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes

Published on: May 22, 2018

10.0K

Complete Tracheal Ring Deformity. A Translational Genomics Approach to Pathogenesis.

Debora I Sinner1,2,3, Brenna Carey4, Daniela Zgherea5

  • 1Division of Neonatology.

American Journal of Respiratory and Critical Care Medicine
|June 20, 2019
PubMed
Summary

Complete tracheal ring deformity (CTRD) is linked to genetic mutations affecting airway development. This study identified variants in Hedgehog and Wnt signaling pathways, crucial for cartilage formation, in patients with CTRD.

Keywords:
cartilageexome sequencingtracheal ringstrachealis muscletracheomalacia

More Related Videos

Hybrid De Novo Genome Assembly for the Generation of Complete Genomes of Urinary Bacteria using Short- and Long-read Sequencing Technologies
12:08

Hybrid De Novo Genome Assembly for the Generation of Complete Genomes of Urinary Bacteria using Short- and Long-read Sequencing Technologies

Published on: August 20, 2021

5.8K
Using In Vivo and Tissue and Cell Explant Approaches to Study the Morphogenesis and Pathogenesis of the Embryonic and Perinatal Aorta
10:57

Using In Vivo and Tissue and Cell Explant Approaches to Study the Morphogenesis and Pathogenesis of the Embryonic and Perinatal Aorta

Published on: September 12, 2017

8.9K

Related Experiment Videos

Last Updated: Jan 23, 2026

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes
09:10

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes

Published on: May 22, 2018

10.0K
Hybrid De Novo Genome Assembly for the Generation of Complete Genomes of Urinary Bacteria using Short- and Long-read Sequencing Technologies
12:08

Hybrid De Novo Genome Assembly for the Generation of Complete Genomes of Urinary Bacteria using Short- and Long-read Sequencing Technologies

Published on: August 20, 2021

5.8K
Using In Vivo and Tissue and Cell Explant Approaches to Study the Morphogenesis and Pathogenesis of the Embryonic and Perinatal Aorta
10:57

Using In Vivo and Tissue and Cell Explant Approaches to Study the Morphogenesis and Pathogenesis of the Embryonic and Perinatal Aorta

Published on: September 12, 2017

8.9K

Area of Science:

  • Genetics
  • Developmental Biology
  • Pediatric Medicine

Background:

  • Complete tracheal ring deformity (CTRD) is a rare congenital condition with unknown causes.
  • CTRD involves continuous cartilaginous tracheal rings, potential airway stenosis, and pulmonary arterial sling.
  • The underlying genetic basis of CTRD requires further investigation.

Purpose of the Study:

  • To investigate the hypothesis that CTRD results from inherited or de novo mutations in genes vital for tracheal development.
  • To identify genetic variants associated with CTRD through whole-exome sequencing.

Main Methods:

  • Microscopic examination of tracheal tissues from CTRD patients and controls.
  • Whole-exome sequencing (trio analysis) in children with CTRD and their parents.
  • Confirmation of mutations via Sanger sequencing and bioinformatic analysis.
  • Comparison with murine models of tracheal development.

Main Results:

  • Absence of the trachealis muscle was observed in all five CTRD patients.
  • Exome analysis revealed de novo, recessive, and compound-heterozygous variants in CTRD patients.
  • Disease-associated variants were identified in SHH (Hedgehog pathway) and HSPG2, ROR2, WLS (involved in Wnt signaling).

Conclusions:

  • Absence of the trachealis muscle is associated with CTRD.
  • Genetic variants in Hedgehog and Wnt signaling pathways are implicated in CTRD.
  • These pathways are critical for cartilage formation and upper airway development.