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Author Spotlight: Investigating the Mechanisms and Inducing Models of Polycystic Ovary Syndrome
Published on: July 5, 2024
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[EFFECT OF MANGANESE AND NICKEL ON PROLACTIN LEVELS IN WOMEN WITH POLYCYSTIC OVARY SYNDROME]
S Gunkov1, T Tatarchuk2, P Zhminko1
11Medved`s research center of preventive toxicology, food and chemical safety, ministry of health Ukraine, Kyiv.
Georgian Medical News
|June 20, 2019
Summary
Manganese exposure may increase prolactin levels in women with polycystic ovary syndrome (PCOS). This study found higher manganese and prolactin levels in PCOS patients, suggesting manganese as a potential factor in PCOS development.
Area of Science:
- Environmental Health
- Endocrinology
- Reproductive Medicine
Background:
- Polycystic ovary syndrome (PCOS) is a common endocrine disorder.
- Environmental factors may influence PCOS development.
- Prolactin levels are often elevated in women with PCOS.
Purpose of the Study:
- To investigate the association between serum manganese and nickel levels and prolactin levels in women with PCOS.
- To compare these levels between women with PCOS and healthy controls.
Main Methods:
- Serum manganese and nickel concentrations were measured using inductively coupled plasma mass spectrometry.
- Prolactin levels were assessed in 35 women with PCOS and 38 healthy women.
- Ecological data was analyzed from open sources.
Main Results:
- Women with PCOS exhibited elevated serum manganese and nickel levels compared to controls.
- Significantly higher prolactin levels were observed in women with PCOS.
- Serum manganese concentrations positively correlated with prolactin levels in PCOS patients (P=0.0134).
- No correlation was found between nickel and prolactin levels in PCOS patients or any correlations in healthy women.
Conclusions:
- Elevated serum manganese levels are associated with increased prolactin in women with PCOS.
- Manganese exposure may be a contributing factor or cofactor in the development of PCOS.
- Nickel exposure does not appear to affect prolactin levels in this population.
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