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Lithium-induced thyroid disorders: a prevalence study.

R Yassa1, A Saunders, C Nastase

  • 1Douglas Hospital Centre, Verdun, Quebec, Canada.

The Journal of Clinical Psychiatry
|January 1, 1988
PubMed
Summary
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Lithium treatment for affective disorders can lead to thyroid issues, with 7.8% of patients developing hypothyroidism. Regular thyroid monitoring is crucial during long-term lithium therapy for mood disorders.

Area of Science:

  • Endocrinology
  • Psychiatry
  • Pharmacology

Background:

  • Lithium is a common mood stabilizer for affective disorders.
  • Thyroid dysfunction is a potential side effect of lithium therapy.
  • Systematic evaluation of thyroid function in lithium-treated patients is necessary.

Purpose of the Study:

  • To systematically examine the prevalence of thyroid disorders in patients undergoing lithium treatment for affective disorders.
  • To assess the incidence of hypothyroidism and other thyroid dysfunctions associated with long-term lithium use.

Main Methods:

  • A cohort of 116 patients (53 men, 63 women) with affective disorders receiving lithium therapy were systematically evaluated.
  • Thyroid function tests, including thyroid-stimulating hormone, thyroxine, and triiodothyronine, were assessed.

Related Experiment Videos

  • Clinical examination for signs of hyperthyroidism and hypothyroidism was performed.

    • Main Results:

    • Nine patients (7.8%) developed hypothyroidism after a mean of 3.4 years of lithium therapy (2 men, 7 women).
    • Two male patients (1.7%) showed elevated thyroid-stimulating hormone without clinical hypothyroidism.
    • One woman developed thyrotoxic nodular goiter, and another experienced temporary increases in thyroxine and triiodothyronine.

    Conclusions:

    • Lithium therapy is associated with a significant risk of developing hypothyroidism.
    • Subclinical thyroid dysfunction and hyperthyroidism can also occur during lithium treatment.
    • Routine thyroid function monitoring is recommended for patients on long-term lithium therapy for affective disorders.